Substituted oximes as neurokinin antagonists

Details Substituted oximes as neurokinin antagonists Substituted oximes as neurokinin antagonists

1998-11-18

2000-05-16

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546189, 546190, 546194, 546217, 546231, C07D40100, C07D21168, C07D21144, C07D21126

Patent

active

060639261

ABSTRACT:
Compounds within the genus represented by the structural formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; ##STR2## R.sup.4 is methyl or ethyl; and Z is substituted piperidinyl.

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patent: 5789422 (1998-08-01), Reichard et al.
Maggi et al, Eur. J. Pharmacol., 166, (1989), p. 435-440.
Ellis et al, J. Pharmacol. Exp. Ther., 267, 1 (1993), p. 95-101.
Chung et al, Molecular Pharmacol., 48 (1995), p. 711-716.
Abstract of FR 2,717,802.

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