Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-07-10
1999-11-23
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548237, 548238, 548239, A01N 4376, C07D26310, C07D26312, C07D26314
Patent
active
059901403
DESCRIPTION:
BRIEF SUMMARY
The invention relates to novel substituted oxazolines, to a number of processes for their preparation, and to their use for combating animal pests.
It is already known that certain oxazoline derivatives have insecticidal and acaricidal properties (cf. EP-A 0 345 775 and EP-A 0 432 661). However, the activity of these previously known compounds, especially at low application rates and concentrations, is not completely satisfactory in all areas of application.
The novel substituted oxazolines of the formula (I) ##STR2## have now been found, in which A represents in each case optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl; phenylalkenyl, phenoxyalkyl or phenyl-thioalkyl;
Depending on the nature of the substituents the compounds of the formula (I) may also be present as geometrical and/or optical isomers or mixtures of isomers of different composition. The invention relates both to the pure isomers and to the isomer mixtures.
Furthermore it has been found that substituted oxazolines of the formula (I) are obtained in that ##STR3## in which B, D, E and G have the meanings given above ##STR4## in which A, B, D, E and G have the meanings given above diluent; or ##STR5## in which A, B, D, E and G have the meanings given above; and arylsulfonyloxy,
Furthermore it has been found that substituted oxazolines of the formula (I) are very highly suited to the combating of animal pests. They are particularly notable for their high level of activity against arthropods and nematodes.
Surprisingly, the substituted oxazolines of the formula (I) according to the invention display a considerably better activity against animal pests than the prior art compounds whose constitution is closest to that of the novel compounds.
A general definition of the compounds according to the invention is given by the formula (I).
A preferably more times by identical or different substituents chosen from halogen, cyano and C.sub.1 -C.sub.4 -alkoxy and from phenyl, phenoxy, benzyloxy, phenylthio and benzylthio, each of which is optionally substituted one to three times by identical or different substituents chosen from halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, C.sub.1 -C.sub.4 -alkylthio and/or C.sub.1 -C.sub.4 -halogenoalkylthio; more times by identical or different halogen substituents; or more times by identical or different substituents chosen from halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.2 -C.sub.4 -alkenyl, C.sub.1 -C.sub.4 -halogenoalkyl or C.sub.2 -C.sub.4 -halogenoalkenyl; substituted one or more times by identical or different substituents chosen from halogen, C.sub.1 -C.sub.4 -alkyl and C.sub.1 -C.sub.4 -halogenoalkyl.
B preferably represents phenyl, benzyl, pheneth-1-yl, pheneth-2-yl, phenoxymethyl, phenylthiomethyl, phenoxyeth-1-yl, phenylthioeth-1-yl, phenoxyeth-2-yl or styryl, each of which is optionally substituted one to four times by identical or different substituents, phenyl substituents which may be mentioned being in each case halogen, oxygen atoms, -alkyl, C.sub.3 -C.sub.6 -cycloalkyl and/or halogen, cyclohexyl and cyclohexyloxy, each of which is optionally substituted by C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, cyclohexyl or phenyl; different substituents chosen from halogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -halogenoalkyl; phenyl, benzyl, phenoxy, phenylthio, benzyloxy and benzylthio, each of which is optionally substituted one to three times by identical or different substituents chosen from C.sub.1 -C.sub.12 -alkyl, halogen, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -halogenoalkoxy, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy-ethyleneoxy, C.sub.1 -C.sub.6 -alkylthio and/or C.sub.1 -C.sub.6 -halogenoalkylthio.
D preferably represents hydrogen or methyl.
E preferably represents hydrogen or methyl.
G preferably represents hydrogen or methyl.
A particularly preferably more times by identical or different substituents chosen from phenyl, p
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Erdelen Christoph
Fischer Reiner
Hagemann Hermann
Holmwood Graham
Kramer Wolfgang
Bayer Aktiengesellschaft
Coleman Brenda
Shah Mukund J.
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