Substituted mandelic acid derivatives and their use in medicamen

Details Substituted mandelic acid derivatives and their use in medicamen Substituted mandelic acid derivatives and their use in medicamen

1992-08-21

1994-03-08

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546123, C07D21516, A61K 3147

Patent

active

052927695

ABSTRACT:
Substituted mandelic acid derivatives can be prepared by reaction of glyoxylic esters with Grignard compounds. The substituted mandelic acid derivatives are suitable as active compounds in medicaments, in particular for medicaments which inhibit leukotriene synthesis.

REFERENCES:
patent: 4952695 (1990-08-01), Groche et al.
Jerry March, Advanced Organic Chemistry, pp. 837-840, (1977).
Houbey-Weyl, Methoden der organischen Chemie, (1973), pp. 289-302.
Uhlmann XII, pp. 367-375, (1976).
R. I. Trust, Organic Synthesis, 1973, pp. 116-122.
O. Grummitt, Org. Synth. Coll., vol. IV, 1963, pp. 771-775.
H. Adkins, Org. Synth. Coll., vol. II, 1943, pp. 606-608.
Gunter E. Jeromin, Chem. Ber., 1987, pp. 649-650.
Pierre Borgeat, Proc. Natl. Acad. Sci USA, May 1979, pp. 2148-2152.

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