Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-06-26
1992-05-19
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514373, 544172, 548110, 548207, 548241, 560 38, 560 39, 568374, C07D26120, C07D27504, A61K 3142, A61K 31425
Patent
active
051149605
ABSTRACT:
Compounds of the formula ##STR1## wherein A taken together with the two carbon atoms denoted as .alpha. and .beta. is a group of the formula ##STR2## and the dotted line is the double bond present in formulas (i) and (iii); and wherein n is zero, 1, 2 or 3, one of R.sup.1 and R.sup.2 is carboxy or alkoxycarbonyl and the other is hydrogen, R.sup.3 is hydrogen, alkyl, alkoxy, aryloxy, azido, cyano or alkylthio, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each, independently, is hydrogen or alkyl or, when R.sup.1 is carboxy or alkoxycarbonyl and n stands for 1, R.sup.4 and R.sup.6 taken together can be a carbon-carbon bond or, when R.sup.2 is carboxy or alkoxycarbonyl, R.sup.5 and R.sup.7 taken together can be a carbon-carbon bond, R.sup.8 is halogen, alkyl, haloalkyl or alkoxy and R.sup.9 is hydrogen, halogen, alkyl or alkoxy, and pharmaceutically acceptable salts of the compounds of formula I in which one of R.sup.1 and R.sup.2 is carboxy and the other is hydrogen with bases, can be used as medicaments for the treatment of rheumatoid arthritis, inflammatory respiratory diseases, inflammatory bowel disease, shock and inflammation associated with ischemia. The compounds of formula I can be prepared according to methods hereinafter described.
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Lawton Geoffrey
Osbond John M.
Self Christopher R.
Bernhardt E.
Gould George M.
Hoffmann-La Roche Inc.
Johnston George W.
Krovatin William
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