Substituted imidazolyl-alkyl-piperazine and -diazepine derivativ

Details Substituted imidazolyl-alkyl-piperazine and -diazepine derivativ Substituted imidazolyl-alkyl-piperazine and -diazepine derivativ

1993-09-20

1996-05-07

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

540575, C07D40306, C07D24308

Patent

active

055148000

ABSTRACT:
Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, m, n and q are defined as in the specification, and the pharmaceutically acceptable salts thereof. The compounds have calcium entry blocking activity with selectivity for cerebral blood vessels, and have protective activity against some of the deleterious effects resultant upon cerebral ischemia.

REFERENCES:
patent: 3362956 (1968-01-01), Archer
patent: 3491098 (1970-01-01), Archer
patent: 4829065 (1989-05-01), Pascal
patent: 5010075 (1991-04-01), Pascal et al.
patent: 5091428 (1992-02-01), Pascal et al.

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