Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1993-02-25
1994-05-17
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 31155
Patent
active
053128400
ABSTRACT:
N,N-disubstituted-guanidines, e.g., of the formula ##STR1## wherein R and R' are substituted or unsubstituted hydrocarbon groups. Methods are provided for the treatment of psychosis and hypertension by administering an effective amount of an N,N'-disubstituted guanidine which, preferably, has a high affinity for the sigma receptor.
REFERENCES:
patent: 1422506 (1922-07-01), Wiess
patent: 1597233 (1926-08-01), Heuser
patent: 1642180 (1927-09-01), Scott
patent: 1672431 (1928-06-01), Schotte
patent: 1756315 (1930-04-01), Ter Horst
patent: 1795738 (1931-03-01), Schotte
patent: 1850682 (1932-03-01), Meis
patent: 1915922 (1933-06-01), Christmann
patent: 2145214 (1939-01-01), Jayne
patent: 2254009 (1941-08-01), Hechenbleikner
patent: 2274476 (1942-02-01), Hechenbleikner
patent: 2362915 (1944-11-01), MacGregor
patent: 2633474 (1953-03-01), Beaver
patent: 3140231 (1964-07-01), Luskin et al.
patent: 3159676 (1964-12-01), Spickett et al.
patent: 3228975 (1966-01-01), Abraham et al.
patent: 3248426 (1966-04-01), Dvornik
patent: 3270054 (1966-08-01), Gagneux et al.
patent: 3283003 (1966-11-01), Jack et al.
patent: 3301755 (1967-01-01), Mull
patent: 3320229 (1967-05-01), Szabo et al.
patent: 3409669 (1968-11-01), Dyke
patent: 3479437 (1969-11-01), Szabo et al.
patent: 3547951 (1970-12-01), Hardie et al.
patent: 3639477 (1972-02-01), L'Italien
patent: 3681459 (1972-08-01), Hughes et al.
patent: 3769427 (1973-10-01), Hughes et al.
patent: 3804898 (1974-04-01), Panneman
patent: 3908013 (1975-09-01), Hughes et al.
patent: 3968243 (1976-07-01), Maxwell et al.
patent: 3976643 (1976-08-01), Diamond et al.
patent: 3976787 (1976-08-01), Hughes et al.
patent: 4007181 (1977-02-01), DuCharme et al.
patent: 4014934 (1977-03-01), Hughes et al.
patent: 4051256 (1977-09-01), Swallow
patent: 4052455 (1977-10-01), Matier et al.
patent: 4109014 (1978-08-01), Liu et al.
patent: 4130663 (1978-12-01), Matier et al.
patent: 4169154 (1979-09-01), Cohen et al.
patent: 4471137 (1984-09-01), Barton et al.
patent: 4575514 (1986-03-01), Carson
patent: 4709094 (1987-11-01), Weber et al.
patent: 4780466 (1988-10-01), Hrib et al.
patent: 4898978 (1990-02-01), Bergfeld et al.
patent: 4906779 (1990-03-01), Weber et al.
patent: 5093525 (1992-03-01), Weber et al.
patent: 5190976 (1993-03-01), Weber et al.
F. Monnet et al., "Multiple Sigma and PCP Receptor Ligands: Mechanism For Neuromodulation and Protection", (1991).
A. Wilson et al., J. Nuclear. Medicine, 31(5):747, abstract no. 376 (1990).
B. Cambell et al., European Journal of Pharmacology, 205:219-233 (1991).
T. Massamiri et al., The Journal of Pharmacology and Experimental Therapeutics, 259(1):22-29 (1991).
S. E. File, TINS, 10:461-463 (1987).
M. W. Scherz et al., J. Med. Chem., 33:2421-2429 (1990).
H. G. M. Westenberg et al., Psychopharmacol. Bull., 23:145-149 (1987).
Adams et al., European Journal. of Pharmacology 142:61-71 (1987).
Bhargava et al., Chemical Abstracts 86:598 (1977).
Bowen et al., European Journal of Pharmacology 147:153-154 (1988).
Campbell et al., Journal of Neuroscience 9(10):3380-3391 (1989).
Dranka et al., Russian Journal of Inorganic Chemistry 26(3):347-350 (1981).
Durant et al., Journal of Med. Chem. 28:1414-1422 (1985).
Geluk et al., Journal of Med. Chem. 12:712-715 (1969).
Kavanaugh et al., Proc. Natl. Acad. Sci. USA 85:2844-2848 (1988).
Keana et al., Proc. Natl. Acad. Sc. 86:5631-5635 (1989).
Maryanoff et al., J. Org. Chem. 51:1882-1884 (1986).
Safir et al., J. Org. Chem. 13:924-932 (1948).
Sonders et al., TINS 11:37-40 (1988).
Stolyarchuk et al., Chemical Abstracts 86:522-523 Abstr. 121071h (1977).
Tester et al., Society for Neuroscience, 19th Annual Meeting p. 983, 396.17 (1989).
Weakley et al., Acta Cryst. C46:2234-2236 (1990).
Weber et al., Proc Natl. Acad. Sci. 83:8784-8788 (1986).
Keana John F. W.
Weber Eckard
Conlin David G.
Corless Peter F.
Henley III Raymond J.
Linek Ernest V.
State of Oregon acting by and through the Oregon State Board of
LandOfFree
Substituted guanidines having high binding to the sigma receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted guanidines having high binding to the sigma receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted guanidines having high binding to the sigma receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-877074