Substituted glutaric acid lactones in the treatment of hyperlipi

Details Substituted glutaric acid lactones in the treatment of hyperlipi Substituted glutaric acid lactones in the treatment of hyperlipi

1989-10-13

1991-08-20

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260410, 560126, 560179, C07C 6976, C07C 6974

Patent

active

050416944

ABSTRACT:
Compounds of formula I ##STR1## are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit .beta.-hydroxy-.beta.-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.

REFERENCES:
CA 90(13):104255m 1978.
CA 90(13):103565a 1978.
CA89(13):106939 1978.
CA 88(3):21433a 1977.
Ikawa, M. Jacs 75 (1953) 1035-1037.

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