Substituted glutaric acid lactones in the treatment of hyperlipi

Details Substituted glutaric acid lactones in the treatment of hyperlipi Substituted glutaric acid lactones in the treatment of hyperlipi

1988-11-07

1990-10-23

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30900, C07D40700

Patent

active

049653733

ABSTRACT:
Compounds of formula I ##STR1## are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit .beta.-hydroxy-.beta.-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthesis of serum cholesterol.

REFERENCES:
Houben-Weyl, Methoden der Organischen Chemie, vol. V1/2 (1963), pp. 778-780, 784-785.

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