Substituted diphenyl indanone, indane and indole compounds and a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514475, 514544, 514546, 514617, 514640, 514717, 549430, 549453, 549550, 558388, 560 56, 560 57, 560221, 564180, 564265, 568659, 568808, 568809, A61K 31335, C07C25500, C07C 6976, C07C 6952

Patent

active

060432721

ABSTRACT:
The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

REFERENCES:
patent: 3546165 (1970-12-01), Morgan
Chem. Abstr., vol. 109, No. 19, Nov. 7, 1998 (Columbus, OH, USA) p. 696, col. 2, the abstract No. 170175x, Nishio, T. et al. "A novel route to indolines by photochemical desulfurization of indoline-2-thiones." J. Chem. Soc. Commun. 1988, (9), 572-3 (Eng).
Chem. Abstr., vol. 105, No. 23, Dec. 8, 1986 (Columbus, OH, USA) p. 531, col. 2, the abstract No. 208158b, Barton, D.H.R. et al. "Pentavalent organobismuth reagents. Part 3. Phenylation of enols and of enolate and other anions." J. Chem. Soc., Perkin Trans. 1, 1985, (12), 2667-75 (Eng).
Chem. Abstr., vol. 94, No. 1, Jan. 5, 1981 (Columbus, OH, USA) p. 368, col. 1, the abstract no. 3984s Bergman, J. et al. "Synthesis and studies of tris-indolobenzenes and related compounds." Tetrahedron 1980, 36 (10), 1445-50 (Eng).
Chem. Abstr., vol. 81, No. 13, Sep. 30, 1974 (Columbus, OH, USA) p. 448, col. 1, the abstract No. 77766j, Isobe, M. et al. "3H-indole. I. General synthetic route of 3,3-disubstituted 3H-indoles via the corresponding oxindoles and the indolines." Yakugaku Zasshi 1974, 94(3), 343-50 (Japan).
Dakkouri et al., Chem. Abstract 126:305266, 1997.
Enokida et al., Chem. Abstract 126:39836, 1996.
Barili et al., Chem. Abstract 107:58774, 1987.
Manning et al., Chem. Abstract 94:102538, 1981.
Starnes, Jr., Chem. Abstract 69:43555, 1968.
Koelsch, Chem. Abstract 55:9360, 1961.
Gagnon, Beilstein Reg. No. 4924895, 1929.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substituted diphenyl indanone, indane and indole compounds and a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted diphenyl indanone, indane and indole compounds and a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted diphenyl indanone, indane and indole compounds and a will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1326419

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.