Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-05-08
2000-12-12
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514210, 514211, 514212, 514218, 5142268, 5142272, 5142278, 5142282, 5142285, 5142332, 5142345, 5142352, 5142358, 5142362, 5142372, 514253, 514255, 514256, 514274, 514321, 514323, 514326, 514338, 514339, 514341, 514343, 514367, 514368, 514372, 514374, 514376, 514378, 514380, 514383, 514384, 514385, 514389, 514394, 514397, 514399, 514406, 514414, 514416, 514417, 514418, 514419, 514422, 514424, 514425, 514427, 514428, 540544, 540553, 540575, 540602, 540603, 544 55, 544 60, 544 61, 544 62, 544 96, 544133, 54413
Patent
active
061599956
ABSTRACT:
Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.
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HCAPLUS printout of WO 97/45402, Dec. 1997.
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Fosang, Amanda J. et al., "Aggrecan Is Degraded by Matrix Metalloproteinases in Human Arthritis: Evidence that Matrix Metalloproteinase and Aggecanase Activities Can Be Independent," J. Clin. Invest., vol. 98, No. 10, pp. 2292-2299 (Nov. 1996).
Roemmele, Renee C. And Rapoport, Henry, "Removal of N-Arylsulfonyl Groups from Hydroxy .alpha.-Amino Acids," J. Org. Chem., vol. 53, pp. 2367-2371 (1988).
Suter, C. M., "Studies in the Diphenyl Ether Series. II. Preparation and Structure of Some Sulfonic Acids and Related Derivatives," J. Am. Chem. Soc., vol. 53, pp. 1112-1116 (1931).
Wang, Su-Sun, "p-Alkoxybenzyl Alcohol Resin and p-Alkoxybenzyloxycarbonylhydrazide Resin for Solid Phase Synthesis of Protected Peptide Fragments," J. Am. Chem. Soc., vol. 95, No. 4, pp. 1328-133 (Feb. 21, 1973).
Ye, Qi-Zhuang et al., "Purification and Characterization of the Human Stromelysin Catalytic Domain Expressed in Escherichia coli," J. Biochemistry, vol. 31, pp. 11231-11235 (1992).
Billen Gunter
Haase Burkhard
Neises Bernhard
Schudok Manfred
Schwab Wilfried
Aventis Pharma Deutschland GmbH
Coleman Brenda
Raymond Richard L.
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