Substituted cycloalkyl derivatives, process for the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S105000

Reexamination Certificate

active

11125757

ABSTRACT:
The present invention relates to compounds of formula 1wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.

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Airapetyan et al.; Isoquinoline derivatives. XXVI. Synthesis of N-arylalkanol derivatives of 4-spiro-substituted 1,2,3,4-tethydroisoquinolines and 1-(3,4-dimethoxyphenyl)-1-cycloalkylmethylamines with beta-adrenoblocking properties; Database Chemabs; Chemical Abstracts Service; Columbus, OH; 1988; Database accession No. 1988:37609; abstract only.
Bertus et al.; Ti(II)-Mediated Conversion of a-Heterosubstituted (O, N, S) Nitriles to Functionalized Cyclopropylamines. Effect of Chelation on the Cyclopropanation Step; Journal of Organic Chemistry; 2002; vol. 67; pp. 3965-3968.
Hass et al.; Carbon Aralkylations of Nitro Paraffins: Journal of Organic Chemistry; 1949; vol. 71; pp. 2290-2291.

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