Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-21
2011-10-18
Fetterolf, Brandon (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S228000, C514S444000, C549S059000
Reexamination Certificate
active
08039492
ABSTRACT:
The present invention provides a substituted cyclic compound of the following general formula I or II:its preparation process and its use as a glucagon-like peptide-1 receptor regulator for preventing or treating metabolic disorders including, but not limited to, diabetes, insulin resistance and obesity, etc.
REFERENCES:
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Schafer et al. Drug Discovery Today 2008, 13 (21/22), 913-916.
Horig et al. Journal of Translational Medicine 2004, 2(44).
Baggio et al “Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo”, Diabetes supplement 3, vol. 53, Dec. 2004.
Tetsuyuki Iwamoto and Setsuo Kashino, “Topochemical Studies. XVI. Direct Observation of the Solid-State Photoreaction of a-(Acetylamino) cinnamic Acid Dihydrate by Single Crystal X-Ray Diffraction,” Department of Chemistry, Faculty of Science, Okayama University, Tsushima, Okayama 700 (Feb. 24, 1993).
Li Na
Liu Qing
Nan Fajun
Wang Guangxing
Wang Mingwei
Baker & Hostetler LLP
Cornet Jean
Fetterolf Brandon
Shanghai Institute of Materia Medica Chinese Academy of Science
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