Substituted benzenesulfonylureas and -thioureas, preparation pro

Details Substituted benzenesulfonylureas and -thioureas, preparation pro Substituted benzenesulfonylureas and -thioureas, preparation pro

1995-06-05

1997-05-20

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514183, 514211, 514212, 5142352, 5142355, 514309, 514414, 514416, 514422, 540451, 540467, 540470, 540524, 540531, 540553, 544127, 544141, 544144, 546141, 546196, 546208, C07D20946, C07D20718, A61K 3140, A61K 3147

Patent

active

056312750

ABSTRACT:
This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation, and uses of the pharmaceutical products based on these compounds. The substituted benzenesulfonylureas and -thioureas are of the formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 E, and y are as defined in the specification. The compounds of formula I have antiarrhythmic activity.

REFERENCES:
patent: 4379785 (1983-04-01), Weyer et al.
patent: 5416105 (1995-05-01), Satoh et al.
Fosset et al., "Identification, Mechanism of Function and Regulation of STP-Sensitive Potassium Channels As Targets For Sulfonylureas Used in the Treatment of Type II Diabetes", Journ. Annu. Diabetol. Hotel-Dieu vol. 111, No. 21, Nov. 20, 1989. Chemical Abstract. No. CA 111:186728q.

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