Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-09-30
1997-03-04
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544365, 544366, 544370, 544393, 544395, C07D40310, A61K 31495
Patent
active
056079362
ABSTRACT:
Disclosed are substituted aryl piperazines of Formula I ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis. In particular compounds of Formula I are shown to be neurokinin antagonists.
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Chiang Yuan-Ching P.
Finke Paul E.
Maccoss Malcolm
Meurer Laura C.
Miller Daniel J.
Gerstl Robert
Merck & Co. , Inc.
Panzer Curtis C.
Rose David L.
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