Substituted acetylenes having retinoid-like biological activity

Details Substituted acetylenes having retinoid-like biological activity Substituted acetylenes having retinoid-like biological activity

1994-12-29

1997-07-15

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560100, 562490, 562492, C07C 6978, C07C 6306

Patent

active

056485140

ABSTRACT:
Compounds of the formula ##STR1## wherein the symbols have the meaning described in the specification, have retinoid-like biological activity.

REFERENCES:
Eyrolles, L. et al. "Retinoid Antagonists: Molecular Design Based on the Ligand Superfamily Concept" Med. Chem. Res (1992) 2:361-367.
Liu, S.S. et al. "Systemic Pharmacokinetics of Acetylenic Retinoids in Rats", Drug Metabolism and Disposition, (1990) 18/6:1071-1077.

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