Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-06-28
2005-06-28
Davis, Zinna Northington (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S144000
Reexamination Certificate
active
06911453
ABSTRACT:
The invention relates to compounds of the formula Iin which R1 to R9 are as defined herein. In one embodiment, these compounds may be used as antihypertensives, for reducing or preventing ischemia-induced damage, as medicaments for surgical intervention for the treatment of ischemias of the nervous system, of stroke and of cerebral edema, of shock, of impaired respiratory drive, for the treatment of snoring, as laxative, as agent against ectoparasites, to prevent the formation of gallstones, as antiatherosclerotics, agents against late complications of diabetes, cancers, fibrotic disorders, endothelial dysfunction, organ hypertrophies and hyperplasias. In one embodiment, the compounds may be inhibitors of the cellular sodium-proton antiporter and influence serum lipoproteins and thus be used for the prophylaxis and for the regression of atherosclerotic lesions.
REFERENCES:
patent: 3666763 (1972-05-01), Grethe et al.
patent: 1 113 007 (2001-07-01), None
patent: WO01/32624 (2001-05-01), None
patent: WO01/32625 (2001-05-01), None
patent: WO01/79186 (2001-10-01), None
patent: WO 03/000194 (2003-01-01), None
Freter et al, Journal of Heterocyclic Chemistry, vol. 17, No. 10, pp. 159-169, 1970.
T. Sattelkau et al., “An Efficient Synthesis of the Potent Dopamine D1Agonist Dinapsoline by Construction and Selective Reduction of 2′-Azadimethoxybenzanthrone”, Synthesis, No. 2, pp. 262-266, (2001).
Esameldin et al., “Alkaloids fromCrinum macowanii”, Biochemical Systematics and Ecology 29, pp. 749-750, 2001.
Ruchirawat et al., “Synthesis of 4-Aryltetrahydroisoquinolines : Application to the Synthesis of Cherylline”, Heterocycles, vol. 55, No. 4, pp. 635-640, 2001.
Honda et al., “Palladium-Catalyzed Intramolecular δ-Lactam Formation of Aryl Halides and Amide-Enolates: Syntheses of Cherylline and Latifine”, Organic Letters, vol. 3, No. 4, pp. 631-633, 2001.
D.T.A. Youssef, “Further alkaloids from the flowers ofPancratium maritimum”, Pharmazie, vol. 54, No. 7, pp. 535-537, 1999.
Couture et al., “Base-induced Cyclization of Trimethoxy-o-Aroyldiphenylphosphoryl methylbenzamide : a Formal Synthesis of (±) Cherylline and (±) Cherylline Dimethylether”, Tetrahedron Letters, vol. 37, No. 21, pp. 3697-3700, 1996.
Hara et al., “A Novel Ring Cleavage and Recyclization of N-Cyanomethyl-1,2,3,4-tetrahydroisoquinolinium Methiodides: A Biomimetic Synthesis of Litebamine”, Tetrahedron vol. 51, No. 37, pp. 10189-10204, 1995.
Bleich Markus
Gekle Michael
Heinelt Uwe
Hofmeister Armin
Lang Hans-Jochen
Aventis Pharma Deutschland GmbH
Davis Zinna Northington
Raymond & Parker, III
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