Substituted 1-oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahy

Details Substituted 1-oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahy Substituted 1-oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahy

1983-11-22

1986-01-14

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

260465F, 26050118, 514319, 514408, 514554, 546206, 548578, 562444, 564304, 564339, A61K 31135, A61K 31205, C07C 9116

Patent

active

045646414

ABSTRACT:
1-Oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahydronaphthalenes of the formula I ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, halogen, trifluoromethyl, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, R.sup.3 is C.sub.1 -C.sub.6 -alkyl and R.sup.4 is hydrogen, C.sub.1 -C.sub.6 -alkyl or benzyl, or R.sup.3 and R.sup.4 together may furthermore be a C.sub.2 -C.sub.5 -alkylene chain, and their salts with physiologically tolerated acids, and their preparation, are described.
The novel compounds are useful active compounds for treating disorders.

REFERENCES:
patent: 2794048 (1957-05-01), Richter et al.
patent: 3135799 (1964-06-01), Bencze
patent: 3410902 (1968-11-01), Draper
patent: 3504031 (1970-03-01), Berdahl et al.
patent: 3862232 (1975-01-01), Lednicer
Journal of Medicinal Chemistry, 1977, vol. 20, No. 5, pp. 699-705, "Analgesic and Tranquilizing Activity of 5,8-Disubstituted 1-Tetralone Mannich Bases".

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