Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-11-14
2006-11-14
Aulakh, Charanjit S. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S094000, C544S126000, C544S361000, C514S233200, C514S253030
Reexamination Certificate
active
07135480
ABSTRACT:
The present invention is directed to substituted 1-benzoyl-3-cyano-pyrrolo[1,2-α]quinolines and analogs thereof, represented by the general Formula I:wherein R1–R8, L, Q, dash line and Ar are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
REFERENCES:
Tewari, R.S. et al.: Studies on 1,3-dipolar cycloaddition reactions of some cycloimmonium Ylides. J. Chem. Eng. Data, vol. 27, pp. 101-103, 1982.
Tewari, R.S. et al.: Studies on 1,3-dipolar cycloaddition reactions of some cycloimmonium Ylides. J. Chem. Eng. Data, vol. 28, pp. 283-285, 1983.
Georgescu, E.I. et al.: N-bridged heterocyclic compounds. Revue Roumaine de Chimie, vol. 46, pp. 357-362, 2001.
Dumitrascu, F., et al., “Primary cycloadducts of 1,10-phenanthrolinium and phthalazinium phenacylides with DMAD,”Tetrahedron Letters42:8379-8382, Elsevier Science Ltd (Sep. 2001).
Henrick, C.A., et al., “Pyridinium Ylids In Synthesis,”Aust. J. Chem.20:2467-2477, Commonwealth Scientific and Industrial Research Organization (1967).
Irwin, W.J., et al., “Pyrrolo[1,2- a]quinolines. A Re-investigation,”J. Chem. Soc. Perkins I2:250-252, The Royal Society of Chemistry (1974).
Kuo, H., et al., “Synthesis and Reaction of 2.7-Dimethylpyrrolo[1,2-a]quinoline with Electrophilic Reagents,”J. Heterocycl. Chem.16:393-395, HeteroCorporation (1979).
Matusiak, G., “1,3-Dipolar Cycloaddition Reactions of the Ylide Derived from 6-Phenacyl-benzo[f][1,7]naphthyridinium Bromide,”Aust. J. Chem.52:149-151, Commonwealth Scientific and Industrial Research Organization (1999).
Wei, X., et al., “A Facile One-step Synthesis of Aromatic Indolizines by 1,3-Dipolar Cycloaddition of Pyridinium and Related Heteroaromatic Ylides with Alkenes in the Presence of TPCD [Copy4(HCrO4)2],”J. Chem. Soc. Perkin Trans. l1:2487-2489, The Royal Society of Chemistry (1993).
International Search Report for International Application No. PCT/US03/39550, U.S. Patent and Trademark Office, mailed on Jun. 22, 2004.
Cai Sui Xiong
Drewe John A
Jiang Sungchun
Kasibhatla Shailaja
Kuemmerle Jared Daniel
Aulakh Charanjit S.
Cytovia, Inc.
Sterne Kessler Goldstein & Fox P.L.L.C.
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