Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-02-23
1997-12-16
Lilling, Herbert J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 78, 536 64, 536 168, A61K 3171, C07H 15252, C12P 1956
Patent
active
056985282
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a new substance IT-62-B, a production process thereof, a medicinal composition containing such a substance and methods of treating an infectious disease caused by bacteria and a tumor, in which such a substance is administered.
BACKGROUND ART
It has heretofore been known that microorganisms produce various substances each having wide features from the viewpoint of chemical structure, and pharmacological activities such as antibacterial activities and antitumor activities.
Accordingly, it is an object of the present invention to provide a substance having far excellent pharmacological activities by using microorganisms.
DISCLOSURE OF THE INVENTION
In view of the foregoing circumstances, the present inventors have isolated many microorganisms from natural soils to retrieve their capability of producing substances having useful pharmacological activities. As a result, it has been found that a Streptomyces sp. strain IT-62 belonging to genus Streptomyces produces a novel substance IT-62-B exhibiting excellent antibacterial activities and antitumor activities, thus leading to completion of the present invention.
TAN-1120 has been reported as a streptomyces-produced substance having a structure similar to that of the compound according to the present invention (Japanese Patent Application Laid Open No. 288892/1990). However, the substance of the present invention is a novel compound having a structure that oxazolidine ring has been additionally ring-condensed.
Namely, the present invention is directed to a substance IT-62-B represented by the following formula (1): ##STR2##
The present invention is also directed to a process for producing the substance IT-62-B, which comprises culturing a microorganism belonging to genus Streptomyces and having capability of producing the substance IT-62-B to produce and accumulate such a compound in the culture fluid and to separate the compound.
The present invention is further directed to a medicine, an antibacterial agent and an antitumor agent each comprising the substance IT-62-B as an active component.
The present invention is still further directed to a medicinal composition comprising the substance IT-62-B and a pharmaceutically permissible carrier.
The present invention is yet still further directed to methods of treating a bacterial infectious disease and a tumor, which each comprise administering an effective amount of the substance IT-62-B to a patient.
The present invention is yet still further directed to use of the substance IT-62-B for a medicine.
BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 illustrates an ultraviolet absorption spectrum of a substance according to the present invention obtained in Example 1.
FIG. 2 illustrates an infrared absorption spectrum of the substance according to the present invention obtained in Example 1.
FIG. 3 illustrates a .sup.1 H-NMR spectrum of the substance according to the present invention obtained in Example 1.
BEST MODE FOR CARRYING OUT THE INVENTION
The substance IT-62-B according to the present invention is represented by the formula (1), and there are isomers based on asymmetric carbon atoms in this compound. However, the present invention includes all of these isomers and mixtures thereof. The substance according to the present invention may exist in the form of a hydrate, and the present invention also include such a hydrate.
The substance IT-62-B according to the present invention can be produced by culturing a strain having capability of producing this substance (hereinafter referred to as "substance IT-62-B-producing strain") under suitable conditions.
The substance IT-62-B-producing strain include microorganisms belonging to genus Streptomyces. As an illustrative example thereof, may be mentioned Streptomyces sp. strain IT-62. This strain is isolated from a soil of the Uigurian province in the People's Republic of China by the present inventors, and was deposited as identification of the microorganism "Strain IT-62", accession number FERM BP-4666 in National
REFERENCES:
patent: 5147860 (1992-09-01), Kanamaru et al.
Chen Ru-Xian
Huang Ming-Yu
Kawauchi Takashi
Matsumoto Hiroshi
Otani Toshio
Lilling Herbert J.
Taiho Pharmaceutical Co. Ltd.
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