Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1994-10-25
1997-03-18
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435118, 435886, C12N 120
Patent
active
056122179
ABSTRACT:
Biotransformation products of a fermentation with culture MA7074 are potent HIV protease inhibitors. These products are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
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patent: 5194378 (1993-03-01), Salituro et al.
patent: 5221625 (1993-06-01), Chen et al.
patent: 5272068 (1993-12-01), Ruby et al.
patent: 5413999 (1995-05-01), Yacca et al.
Arison Byron H.
Chen Shieh-Shung T.
Garrity George M.
Heimbuch Brian
Miller Randall R.
Appollina Mary A.
Lilling Herbert J.
Merck & Co. , Inc.
Winokur Mel
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