Streptolysin O derivatives

Details Streptolysin O derivatives Streptolysin O derivatives

1991-08-30

1995-01-03

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 691, 4352523, 4353201, 536 221, 536 231, 536 232, 536 237, C12N 900, C12N 120, C12P 2106, C07H 1900

Patent

active

053786203

ABSTRACT:
Disclosed herein are derivatives of Streptolysin 0 produced by recombinant DNA techniques. In an embodiment, the derivative is soluble upon expression and has a specific hemolytic activity of about 3.6.times.10.sup.4 hemolytic units per milligram.

REFERENCES:
patent: 4925799 (1990-05-01), Rosenberg
Kehoe et al. "Cloning and Expression in Escherichia coli of the Streptolysin O Determinant from Streptococcus pyogenes"; Infect Imm. 43:804-810 (1984).
Kehoe, M. A. et al. "Nucleotide Sequence of the Streptolysin O (SLO) Gene: Structural Homologies between SLO and Other Membrane-Damaging, Thiol-Activated Toxins"; Infect. Imm. 55:3228-3232 (1987).
Becker, J. et al. "Nephelometric Determination of Antistreptolysin O." AACC 1991 Meeting, Washington, D.C. (Aug. 1, 1991).
Shatzman, A. R. & Rosenberg, M. "Expression Identification, and Characterization of Recombinant Gene Products in Escherichia coli." Methods in Enzymology 152:661-675 (1987).
Shatzman, A. R. & Rosenberg, M. "The pAS Vector System and Its Application to Heterologous Gene Expression in Escherichia coli." Hepatology 7:305-355 (1987).
Degnen, G. A. & Cox, E. C. "Conditional Mutator Gene in Escherichia coli: Isolation, Mapping and Effector Studies." J. Bacter. 117:477-487 (1987).
Echols, H. et al. "Mutator Strains of Escherichia coli, mutD and DnaQ, with defective exonucleolytic editing by DNA polymerase III holoenzyme." PNAS USA 80:2189-2192 (1983).
Schaaper, R. M. "Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: Role of DNA mismatch repair." PNAS USA 85:8126-8130 (1986).
Alouf, J. E. "Streptococcal Toxins (Streptolysin O, Streptolysin S, Erythrogenic Toxin)." Pharmac. Ther. 11:661-717 (1980).

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