Steroid derivatives useful as hypocholesterolemics

Details Steroid derivatives useful as hypocholesterolemics Steroid derivatives useful as hypocholesterolemics

1990-09-28

1991-08-20

Sneed, Helen M. S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514178, 514182, 514824, 514176, A61K 3156

Patent

active

050414321

ABSTRACT:
Lanosterols substituted in the 14 and/or 15 position(s) which are active in inhibiting lanosta-8,24-dien-3.beta.-ol 14.alpha.-methyl-demethylase activity, suppressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) activity, decreasing cholesterol synthesis and reducing serum cholesterol levels are disclosed.

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