Stereoselective glycosylation process for preparing 2'-Deoxy-2',

Details Stereoselective glycosylation process for preparing 2'-Deoxy-2', Stereoselective glycosylation process for preparing 2'-Deoxy-2',

1994-11-17

1997-02-25

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2712, 536 2721, 536 276, 536 278, 536 2781, 536 281, 536 283, 536 284, 536 285, 536 2852, 536 2853, 536 2855, 536 2854, C07H 100, C07H 1900

Patent

active

056060483

ABSTRACT:
A stereoselective glycosylation process for preparing beta- and alpha-anomer enriched 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides by reacting a concentrated alpha- or beta-anomer enriched 2 -deoxy-2,2-difluorocarbohydrate or 2-deoxy-2 -fluorocarbohydrate with at least a molar equivalent of a nucleobase derivative in a high boiling inert solvent.

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