Coating processes – Particles – flakes – or granules coated or encapsulated – Solid encapsulation process utilizing an emulsion or...
Patent
1990-06-25
1993-02-02
Stoll, Robert L.
Coating processes
Particles, flakes, or granules coated or encapsulated
Solid encapsulation process utilizing an emulsion or...
4272133, 264 41, 264 46, 264204, 26421111, 26421112, 426 96, 424493, 424499, B01J 1304, A29C 4700, A61K 962, A61K 916
Patent
active
051836904
ABSTRACT:
Biologically active agents to be encapsulated are continuously blended with a starchy material and water, subjected to high-shear mechanical action at a temperature above the gelatinization temperature of starch, and continuously recovered as an insolubilized matrix of starch that entraps discontinuous domains of the agent. Alternatively, the core material to be encapsulated is added and blended with the aqueous dispersion of starch after the starch and water have been subjected to an elevated temperature sufficient to gelatinize the starch. Rate of release of agents to the environment can be controlled by preselecting a set of conditions related to various processing parameters. Encapsulation of biologically active compositons provides protection against degradative environmental conditions, improves safety in handling, and slows the release of such compounds to the surrounding medium.
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Bagley Edward B.
Carr Merle E.
Doane William M.
Wing Robert E.
Covert John M.
Fado John D.
Ribando Curtis P.
Silverstein M. Howard
Stoll Robert L.
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