Stable soluble 1,2-diaminocyclohexane platinum complexes

Details Stable soluble 1,2-diaminocyclohexane platinum complexes Stable soluble 1,2-diaminocyclohexane platinum complexes

1985-12-26

1987-07-14

Sneed, Helen M. S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

556137, C07F 1500

Patent

active

046803084

ABSTRACT:
Platinum complexes of the formula ##STR1## wherein Z is --CO-- or a single bond and R is --COOH or --SO.sub.3 H, and the pharmaceutically acceptable salts thereof with bases, are stable readily water-soluble pharmaceutically active compounds having antitumor, anti-inflammatory and trypanocidal activities.

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patent: 4200583 (1980-04-01), Kidani et al.
patent: 4242430 (1980-12-01), Hara et al.
patent: 4560781 (1985-12-01), Totani et al.
patent: 4565884 (1986-01-01), Andrulis, Jr. et al.
Ridgway et al, J. Clin. Hematol. Oncol. 7 (1), pp. 220-230, (1977).

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