Stable prostaglandin-containing compositions

Details Stable prostaglandin-containing compositions Stable prostaglandin-containing compositions

2006-01-20

2011-12-27

Westerberg, Nissa (Department: 1618)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C424S078040

Reexamination Certificate

active

08084501

ABSTRACT:
A pharmaceutical composition containing a prostaglandin and an alkanoic acid ester of a polyethoxylated sorbitol in an amount effective to enhance the chemical stability of the prostaglandin, and the use thereof for treating ophthalmic conditions. Also disclosed are methods for enhancing the chemical stability of a prostaglandin-containing composition by using an alkanoic acid ester of a polyethoxylated sorbitol.

REFERENCES:
patent: 1366215 (1921-01-01), Ruths
patent: 5165918 (1992-11-01), Heyl et al.
patent: 5631287 (1997-05-01), Schneider
patent: 5670537 (1997-09-01), Canetta et al.
patent: 5849792 (1998-12-01), Schneider
patent: 5889052 (1999-03-01), Klimko et al.
patent: 5972991 (1999-10-01), Burk
patent: 6011062 (2000-01-01), Schneider et al.
patent: 6235781 (2001-05-01), Weiner et al.
patent: 6319943 (2001-11-01), Joshi et al.
patent: 6417228 (2002-07-01), Klimko
patent: 6743439 (2004-06-01), Castillo et al.
patent: 2002/0103255 (2002-08-01), Hellberg et al.
patent: 2003/0147823 (2003-08-01), Woodward et al.
patent: 2004/0023954 (2004-02-01), Ling et al.
patent: 2004/0076678 (2004-04-01), Ueno
patent: 2004/0082660 (2004-04-01), Ueno
patent: 2004/0097592 (2004-05-01), Morishima et al.
patent: 704670 (1998-10-01), None
patent: 0603800 (1994-06-01), None
patent: 1 321 144 (2003-06-01), None
patent: WO-95/18102 (1995-07-01), None
patent: WO 98/41208 (1998-09-01), None
patent: WO-99/02164 (1999-01-01), None
patent: WO-99/02165 (1999-01-01), None
patent: WO-99/12899 (1999-03-01), None
patent: WO-00/20386 (2000-04-01), None
patent: WO-00/40248 (2000-07-01), None
patent: WO-02/38158 (2002-05-01), None
patent: WO-2004/022063 (2004-03-01), None
Product page for Sigma T6687 from www.sigmaldrich.com, accessed Dec. 4, 2007.
Alexander et al., Annals of Pharmacotherpay, 36(3), p. 504-511, 2002.
BASF Technical Leaflet, “Cremophor EL”, pp:1-7, Jul. 1997.
Kerstetter el al., “Prostaglandin F2 Alpha-1-Isopropylester Lowers Intraocular Pressure Without Decreasing Aqueous Humor Flow”,J. Ophthalmol, 105:30-34 (1988). (abstract).
Oda et al., Cell Injury Effect of Isopropyl Unoprostone, an Antiglaucoma Agent, on Cultured Human Conjunctival Cells,J. Ocul Pharmacol Ther., 15:489-496 (1999). (abstract).
Tabassi et al., The Effects of Polysorbate Surfactants on the Structure of Mucus Glycoproteins, http://diglib.tums.ac.ir/U.j/daru/vol9n12/sajjadi.htm, pp:1-10 (2004).
Ciucanu et al., “Derivatizations of prostaglandins and related compounds to (methoxime) alkyl ester alkyl ether derivatives for gas chromatographic analysis,”Chemical Abstracts, 109:664 (1988).
Ikegami et al., “9,15-Bis(arylsilyl)prostaglandin F2α derivatives,”Chemical Abstracts, 105:650 (1986).
Lijebris et al., “Ligand-controlled palladium-catalyzed intramolecular reactions of phenyl-substituted prostaglandin F2α analogues,”Tetrahedron, 51:9139-9154 (1995).
Miyazaki et al., “Dimethylisopropylsilyl ether derivatives in gas chromatography mass spectrometry fo prostaglandins and thromboxane B2,”Chemical Abstracts, 96:90-91 (1982).
Morozowich et al., “Prostaglandin prodrugs. II: New method for synthesizing prostaglandin C1-aliphatic esters,”Chemical Abstracts, 91:603 (1979).
Waddell et al., “Combined capillary column gas chromatography negative ion chemical ionization mass spectrometry of prostanoids,”Chemical Abstracts, 99:87498 (1983).
European Search Report for corresponding Application No. 06178670.0, dated Mar. 18, 2008.
United Kingdom Intellectual Property Office Search Report for corresponding Application No. GB0501192.9, dated Apr. 19, 2005.
International Search Report for corresponding International Application No. PCT/US2006/001626, dated Jul. 25, 2006.
Written Opinion of the International Searching Authority for corresponding International Application No. PCT/US2006/001626, dated Jul. 25, 2006.
International Preliminary Report on Patentability for corresponding International Application No. PCT/US2006/001626, dated Jul. 24, 2007.

Affiliated with

Also associated with

Rating

Stable prostaglandin-containing compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stable prostaglandin-containing compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stable prostaglandin-containing compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4253778