Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1994-06-10
1996-09-24
Kight, John
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 11, 435 13, 435 15, 435 16, 435 18, 435 25, 436 11, 436 15, C12Q 100, C12Q 160, C12Q 156, G01N 3100
Patent
active
055589855
ABSTRACT:
A reference solution for calibrating and monitoring blood gas instrumentation that has a shelf line of two years or greater is disclosed. The solution is contained in a closed container having a gas or gas mixture that is inert to the reference solution and comprises an aqueous mixture containing a hemoglobin, a source of bicarbonate ions and an organic buffer. The solution optionally contains a methemoglobin reducing system, reference concentrations of selected electrolytes, a polyphosphate compound and antibiotics. The ampule is subsequently opened and the solution is equilibrated with a gas mixture having components which provide gasses in a physiological range to the solution. The solution is characterized by exhibiting properties similar to fresh blood subsequent to equilibration.
REFERENCES:
patent: 3973913 (1976-08-01), Louderback
patent: 4163734 (1979-08-01), Sorensen et al.
patent: 4189401 (1980-02-01), Louderback
patent: 4199471 (1980-04-01), Louderback et al.
patent: 4279775 (1981-07-01), Louderback et al.
patent: 4289648 (1981-09-01), Hoskins et al.
patent: 4299728 (1981-11-01), Cormier et al.
patent: 4301117 (1981-11-01), Smernoff
patent: 4401652 (1983-08-01), Simmonds et al.
patent: 4469792 (1984-09-01), Simmonds et al.
patent: 4485174 (1984-11-01), Chiang et al.
patent: 4711852 (1987-12-01), Jacobson
patent: 4753888 (1988-06-01), Chiang
patent: 4843013 (1989-06-01), Chiang
patent: 4945062 (1990-07-01), Chiang
patent: 5013666 (1991-05-01), Chiang
patent: 5045529 (1991-09-01), Chiang et al.
patent: 5304491 (1994-04-01), Chiang et al.
Chanutin, A. and Curnish, R., "Effect of Organic and Inorganic Phosphates on the Oxygen Equilibrium of Human Erythrocytes", Archives of Biochemistry and Biophysics, 121:96-102 (1967).
Benesch, R. and Benesch, R. E., "Intracellular Organic Phosphates as Regulators of Oxygen Release by Haemoglobin", Nature, 221:618-622 (1969).
Masukawa, T. and Iwata, H., "Catalytic Action of Selenium in the Reduction of Methemoglobin by Glutathione", Life Sciences, 21:695-700 (1977).
Mansouri, A., "Hemoglobin Autoxidation Under High Oxygen Pressure Effect of Inositol Hexaphosphate", Hemoglobin, 5(6):579-589 (1981).
Feola, M. et al., "Development of a Bovine Stroma-Free Hemoglobin Solution as a Blood Substitute", Surgery, Gynecology & Obstetrics, 157(5):399-408 (Nov. 1983).
Sprokholt, R., et al. "Quality Control Material Containing Hemoglobin for Blood Gas and pH Measurement: Preparation of Stroma-free Hemoglobin Solution", Scand J. Clin. Lab. Invest., 47 (188):69-82 (1987).
Matteucci, M. D. and Caruthers, M. H., "Synthesis of Deoxyoligonucleotides on a Polymer Support", J. Am. Chem. Soc., 103 (31):3185-3191 (1981).
International Search Report dated 28 Jun. 1990 PCT application PCT/US90/01422.
Sprokholt, R. and Maas, A. H. J., "Evaluation of Ampouled pH and Blood Gas Quality Control Material (Prime) Based on a Stroma-Free Hemoglobin Solution (SFHS), "IFCC Workshop OSLO (1983).
Chiang Ching
Liffman Stanley M.
Bionostics Incorporated
Kight John
Leary Louise N.
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