Stable formulation of enalapril salt, a process for the preparat

Details Stable formulation of enalapril salt, a process for the preparat Stable formulation of enalapril salt, a process for the preparat

1992-11-24

1994-09-27

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 514970, A61K 920

Patent

active

053505824

ABSTRACT:
There is disclosed a stable formulation of enalapril salt of the formula I ##STR1## which is prepared in such manner that a compound of formula II ##STR2## is suspended in demineralized water and a stoichiometric amount of the corresponding sodium compound such as sodium carbonate, sodium hydrogen carbonate or sodium hydroxide is added thereto, to this enalapril sodium salt prepared in situ of the formula I ##STR3## formulating additives are added, the whole is homogenized and formulated.

REFERENCES:
patent: 4743450 (1988-05-01), Harris et al.
patent: 4830853 (1989-05-01), Murthy et al.

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