Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Peroxide or compositions of or releasing gaseous oxygen or...
Patent
1993-12-09
1996-04-16
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Peroxide or compositions of or releasing gaseous oxygen or...
424639, 424646, 514557, A61K 3340, A61K 3332, A61K 3326
Patent
active
055080464
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates generally to the field of microbicides. In particular, it relates to a stable microbicide having anticorrosive properties comprising a mixture of hydrogen peroxide, peracetic acid, acetic acid and purified water which is substantially free of contaminants or stabilizing and sequestrant type additives.
2. Description of the Related Art
Peracetic acid/peroxide containing compositions have a long history of use as disinfectants and sterilizers due to their microbicidal activities. However, peroxide containing compositions are high-energy-state compounds and as such can be considered thermodynamically unstable. Therefore, because there is a strong tendency for these compositions to decompose in the presence of multivalent metal ions, stabilizers are added. Stabilizers may be agents such as sodium pyrophosphate, phosphonic acid or chelating agents such as 8-hydroxyquinoline. Stabilizers act by removing trace metals which accelerate the decomposition of peroxides. Stabilizers also accelerate the reaction between hydrogen peroxide and acetic acid to form peracetic acid. Therefore, for any given concentration of hydrogen proxide and acetic acid, the addition of a stabilizer increases the concentration at equilibrium of peracetic acid.
While conventional art compositions are stable due to the use of added stabilizers, they are also highly corrosive to the very metals they are designed to disinfect namely surgical and dental instruments made of aluminum or brass, which instruments are often plated with an ornamental or protective layer of nickel or nickel and/or chromium. Additionally, certain susceptible individuals often exhibit allergic reactions to the conventional art formulations. Further, after prolonged use these conventional art formulations often leave mineral-like deposits on the metal instruments they sterilize.
A concentrated composition that contains no stabilizer or sequestrant type additives that is both stable during storage for prolonged periods of time and possesses anticorrosive properties would be a decided advantage over these conventional formulations. Further, a use-dilution formulation that may be reused several times, is stable for relatively long periods in the diluted form and possesses anticorrosive properties would be a further advantage over conventional formulations.
SUMMARY OF THE INVENTION
It is an object of the stable, anticorrosive concentrate and use-dilution microbicides in accordance with the present invention to solve the problems outlined above that has heretofore inhibited long-term storage and the anticorrosive sterilization of surgical and dental instruments. These improved microbicide solutions not only have the desired stability but have been shown to have a significantly reduced corrosive effect on certain metals than those of conventional art mixtures of the peracetic acid/peroxide types known to the applicants.
In accomplishing the foregoing objectives, there has been provided in accordance with the present invention a stable, anticorrosive to surgical and dental metals concentrate including peracetic acid, acetic acid, hydrogen peroxide and purified water mixed in a ratio of from about one to eleven parts total acid to one part hydrogen peroxide. The new concentrate has from substantially about 0.001 ppm to 200 pm, more preferably from about 0.001 ppm to 100 ppm, and most preferably from about 0.001 ppm to 10 ppm of added stabilizers, such as phosphonic acids, sodium pyrophosphates and from about 0.001-10 ppm of ionic and non-ionic contaminants such as divalent and trivalent ions, with no added surfactants, such as ethoxylated decyl alcohols, sulfonate and sulfate types.
In accordance with another aspect of the present invention, there has been provided a stable, anticorrosive to surgical and dental metals use-dilution formulation including a concentrate consisting essentially of at equilibrium peracetic acid, acetic acid, hydrogen peroxide and an aqueous diluent, said concentrate charac
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Cosentino Louis C.
Hall Kimberly L.
Hall, II Robert T.
Jansen Walter B.
Marino Rosario M.
Buharin Amelia A.
Fay Zohreh
Minntech Corporation
Wrigley Barbara A.
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