N-acylated-11-oxygenated-2,6-methano-3-benzazocine intermediates

Details N-acylated-11-oxygenated-2,6-methano-3-benzazocine intermediates N-acylated-11-oxygenated-2,6-methano-3-benzazocine intermediates

1974-02-21

1977-02-22

Todd, G. Thomas

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260DIG13, 424267, C07D22126

Patent

active

040091716

ABSTRACT:
11-Oxygenated-2,6-methano-3-benzazocines N-alkylated by alkylmethyl, haloalkenylmethyl, alkynylmethyl, cycloalkylmethyl, cycloalkenylmethyl, cycloalkyl or 2-cycloalkenyl are prepared directly by N-alkylation of the corresponding N-H intermediates or indirectly by N-acylation of the corresponding N-H intermediates followed by reduction of the resulting N-acylated intermediates and are useful as antagonists of narcotic analgesics.

REFERENCES:
patent: 2733330 (1973-05-01), Schubert et al.
patent: 3639407 (1972-02-01), Clarke et al.
patent: 3700734 (1972-10-01), Robinson et al.
patent: 3891657 (1975-06-01), Monkovic et al.
Saito et al., J. Org. Chem. 26, 4536-4540 (1961).

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