Stabilized benzimidazole derivative and composition

Details Stabilized benzimidazole derivative and composition Stabilized benzimidazole derivative and composition

1989-07-13

1994-03-15

Richter, Johann

Drug, bio-affecting and body treating compositions

Digestive system regulator containing solid synthetic...

424451, 424452, 424456, 424463, 424464, 424465, 424474, 424480, 424485, 424486, 514212, 514338, 514395, 540603, 5483071, 546199, A61K 3141, A61K 31415, A61K 3174

Patent

active

052944395

ABSTRACT:
A stabilized physiologically active benzimidazole derivative having the formula (I): ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a fluoroalkyl group having 1 to 6 carbon atoms, a cycloalkyl group, phenyl group or an aralkyl group, R.sup.2 is hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form a ring, and each of R.sup.3a, R.sup.3b, R.sup.4a, R.sup.4b and R.sup.4c independently is hydrogen atom, a halogen atom, a fluoroalkyl group having 1 to 6 carbon atoms, a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or an amino group. The stabilized benzimidazole derivative is in amorphous form or present in contact with a basic material.

REFERENCES:
Ritschel. Applied biopharmacy, pp. 293-303 (1973).

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