Stabilization process for biological cells and stabilized compos

Details Stabilization process for biological cells and stabilized compos Stabilization process for biological cells and stabilized compos

1980-07-14

1983-06-28

Hunt, Brooks H.

Chemistry: analytical and immunological testing

Composition for standardization, calibration, simulation,...

Particle count or volume standard or control

436 11, 436 17, 435183, G01N 3348

Patent

active

043906320

ABSTRACT:
Biological cell compositions are stabilized to preserve aldehyde functionality by formation of acetal, particularly cyclic acetal, primarily in order to prevent cell-to-cell crosslinking. The stabilized biological cells are particularly useful as human blood particle analogs in reference reagents employed in electronic hematology testing instrumentation.
A process for preparing the acetal-stabilized biological cells employs reaction of polyaldehyde-treated biological cells with alcohol, preferably including 1,2 dialcohol, under acidic conditions; thereafter, the resulting product solution is adjusted to basic condition, stabilizing the acetal formation on the biological cells.

REFERENCES:
patent: 3322634 (1967-05-01), Fulthorpe
patent: 4198206 (1980-04-01), Ryan
patent: 4199471 (1980-04-01), Louderback

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