Stabilization of somatotropins and other proteins by modificatio

Details Stabilization of somatotropins and other proteins by modificatio Stabilization of somatotropins and other proteins by modificatio

1995-02-06

1999-09-14

Ulm, John

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 854, 514 12, 530399, 530402, 530381, A61K 3819, A61K 3827, A61K 3818

Patent

active

059519720

ABSTRACT:
The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing the derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4847325 (1989-07-01), Shadle et al.
patent: 5037806 (1991-08-01), Krivi
patent: 5153265 (1992-10-01), Shadle et al.
patent: 5166322 (1992-11-01), Shaw et al.
patent: 5183660 (1993-02-01), Ikeda et al.
patent: 5206344 (1993-04-01), Katre et al.
patent: 5217954 (1993-06-01), Foster et al.
patent: 5223483 (1993-06-01), Thomas et al.
patent: 5302702 (1994-04-01), Seddon et al.
patent: 5310883 (1994-05-01), Seddon et al.
Veronese et al. J. Pharm. Pharmacol. 35: 757-758, 1983.
Veronese et al., "Anti-inflammatory and pharmakokinetic properties of superoxide dismutase derivatized with poly-ethylene glycol via active esters," J. Pharm. Pharmacol. 35: 757-758 (1983).

Affiliated with

Also associated with

Rating

Stabilization of somatotropins and other proteins by modificatio does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilization of somatotropins and other proteins by modificatio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilization of somatotropins and other proteins by modificatio will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1507905