Stabilization of pleuromutilin derivatives against oxidation by

Details Stabilization of pleuromutilin derivatives against oxidation by Stabilization of pleuromutilin derivatives against oxidation by

1981-03-06

1983-06-28

Wyse, Thomas G.

Food or edible material: processes, compositions, and products

Products per se, or processes of preparing or treating...

Containing antioxidant or antioxidant per se

424149, 424305, 424311, A61K 3122

Patent

active

043905587

ABSTRACT:
A composition and method which provides a compound of the formula I: ##STR1## wherein either R.sub.1 is ethyl or vinyl. n is an integer from 2 to 5 and each of R.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms.
Also provided is a hypochlorite scavenger in solution with the formula I compound which stabilizes the compound against oxidation by sodium hypochlorite.
A preferred solution contains the compound of formula I wherein R.sub.1 is vinyl, R.sub.2 and R.sub.3 are ethyl as a salt of hydrogen fumarate i.e. tiamulin hydrogen fumarate. The solution is added to drinking water which is fed to farm animals as treatment for mycoplasma infection.

REFERENCES:
patent: 2927859 (1960-03-01), Gordon

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