Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1978-08-11
1979-04-03
Trousof, Natalie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548309, A61K 31415, C07D49110
Patent
active
041477979
ABSTRACT:
Novel spiro-furanohydantoin derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The compounds include 2-methyl-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione, 2-fluoro-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione, 2-chloro-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione, 2-bromo-spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione and spiro-[cyclohexa(b)furan-4,4'-imidazolidine]-2',5'-dione.
REFERENCES:
patent: 3821383 (1974-06-01), Sestanj
patent: 4117230 (1978-09-01), Sarges
Kelbaugh Paul R.
Sarges Reinhard
Harkaway Natalia
Knuth C. J.
Murphy F. X.
Nelson A. J.
Pfizer Inc.
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