Sphingosine kinase enzyme

Details Sphingosine kinase enzyme Sphingosine kinase enzyme

2006-09-26

2006-09-26

Monshipouri, Maryam (Department: 1653)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C530S350000, C424S094500

Reexamination Certificate

active

07112427

ABSTRACT:
The present invention relates generally to novel protein molecules and to derivatives, analogues, chemical equivalents and mimetics thereof capable of modulating cellular activity and, in particular, modulating cellular activity via the modulation of signal transduction. More particularly, the present invention relates to human sphingosine kinase and to derivatives, analogues, chemical equivalents and mimetics thereof. The present invention also contemplates genetic sequences encoding said protein molecules and derivatives, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications.

REFERENCES:
patent: 6525174 (2003-02-01), Young et al.
patent: WO 99/12533 (1999-03-01), None
patent: WO 99/61581 (1999-12-01), None
patent: WO 00/05365 (2000-02-01), None
patent: WO 00/52173 (2000-09-01), None
patent: WO 00/55332 (2000-09-01), None
Altschul, S., et al; “Basic Local Alignment Search Tool”;J. Mol. Biol.(1990); vol. 215; pp. 403-410.
Alessenko; A. V., “Review: Functions of Sphingosine in Cell Poliferation and Death”;Biochemistry(1998); vol. 63; pp. 62-68; [online] [retrieved on Aug. 28, 2003]. Retrieved from Internet: <URL: http://www.protein.bio.msu.su/biokhimiya/contents/v63/full/63010075.htm>.
Bonner; T., “Reduction in the Rate of DNA Reassociation by Sequence Divergence”;Mol. Biol.(1973); vol. 81: pp. 123-135.
Bradford; M., “A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding”;Analytical Biochemistry(1976): vol. 72; pp. 248-254.
Buehrer, Benjamin and Robert Bell; “Inhibition of Sphingosine Kinasein Vitroand in Platelets”;Journal of Biological Chemistry(1992); vol. 267; No. 5, pp. 3154-3159.
Buehrer, Benjamin and Robert Bell; “Sphingosine Kinase: Properties and Cellular Functions”;Advances in Lipid Research(1993); vol. 26; pp. 59-67.
Buehrer, B., et al; “Protein Kinase C-dependent Regulation Of Human Erythroleukemia (HEL) Cell Sphingosine Kinase Activity”;Biochimica et Biophysica Acta(1996); vol. 1303; pp. 233-242.
Cuvillier et al; “Suppression of Ceramide-Mediated Programmed Cell Death by Sphingosine-1-phosphate”;NATURE(1996); vol. 381; pp. 800-803.
Douillard et al; “Basic Facts About Lymphocyte Hybridomas”;Basic Facts About Hybridomas in Compendium of Immunology(1981); vol. II; pp. 119-219; ed. Schwartz.
Duggleby, R.G, “A Nonlinear Regression Program for Small Computers”;Analytical Biochemimistry(1981); vol. 110; pp. 9-18.
Graham, F. L. and A. Van Der Eb; “Transformation of Rat Cells by DNA of Human Adenovirus 5”;VIROLOGY(1973); vol. 54; pp. 536-539.
Igarashi; Yasuyuki, “Functional Roles of Sphingosine 1-Phosphate, and Methylsphingosines: In Regard to Membrane Sphingolipid Signaling Pathways”;J. BIOCHEM.(1997); vol. 122; pp. 1080-1087.
Kohama et al; “Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase”;Journal of Biological Chemistry(1998); vol. 273; No. 37, pp. 23722-23728.
Laemmli; U. K., “Cleavage of Structural Proteins During the Assembly of the Head of Bacteriophage T4”;NATURE(Aug. 15, 1970); vol. 227; pp. 680-685.
Louie, D. D., et al; “Sphingolipid Base Metabolism: Partial Purification and Properties of Sphinganine Kinase Of Brain”;The Journal of Biological Chemistry.(Aug. 10, 1976); vol. 251; No. 15 pp. 4557-4564.
Masai et al; “Drosophilaretinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats”;Proc. Natl. Acad. Sci. USA(1993); vol. 90; pp. 11157-11161.
Melendez et al; “FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking”; Journal of Biological Chemistry, (1998).; vol. 273; No. 16, pp. 9393-9402.
Meyer Zu Heringdorf et al; “Molecular Diversity of Sphingolipid Signalling”;-FEBS LETTERS(1997); vol. 410; pp. 34-38.
Nagiec et al; “TheLCB4(YOR171c) andLCB5(YLR260w) Genes ofSaccharomycesEncode Sphingoid Long Chain Base Kinases”; Journal of Biological Chemistry, (1998); vol. 273; No. 31, pp. 19437-19442.
Olivera et al; “Sphingosine-1-phosphate as second Messenger in Cell Proliferation Induced by PDGF and FGS Mitogens”;NATURE(Oct. 7, 1993); vol. 365; pp. 557-560.
Olivera et al; “Purification and Characterization of Rat Kidney Sphingosine Kinase”; The Journal of Biological Chemistry, (May 15, 1998); vol. 273; No. 20, pp. 12576-12583.
Ponting et al'; “SMART: Identification And Annotation Of Domains From Signalling And Extracellular Protein Sequences.”;Nucleic Acids Research(1999); vol. 27; No. 1, pp. 229-232.
R. Ren et al; “Identification of a Ten-Amino Acid Proline-Rich SH3 Binding site”;SCIENCE(Feb. 19, 1993); vol. 259; pp. 1157-1161.
Rhoads et al; “Sequence Motifs For Calmodulin Recognition”;FASEBJournal (1997); vol. 11; pp. 331-340.
Sakane et al; “The C-terminal Part Of Diacylglycerol Kinase α Lacking Zinc Fingers Serves As A Catalytic Domain”; BIOCHEM J. (1996); vol. 318; pp. 583-590
Saraste et al; “The P-loop-a Common Motif in ATP- and GTP- Binding Proteins”Trends Biochem. Sci.(Nov. 1990); vol. 15; pp. 430-434.
Schaap et al; “Consensus Sequences for ATP-binding Sites In Protein Kinases Do Not Apply To Diacylglycerol Kinases”;Biochemical Journal(1994); vol. 304; pp. 661-662.
J. Schultz et al; “SMART, A Simple Modular Architecture Research Tool: Identification Of Signaling Domains”;Proc. Natl, Acad. Sci., USA, (1998); vol. 95; pp. 5857-5864.
Smith et al; “Measurement of Protein Using Bicinchoninic Acid”;Analytical Biochemistry(1985); vol. 150; pp. 76-85.
Spiegel et al; “REVIEW: Roles of Sphingosine-1-phosphate in Cell Growth, Differentiation and Death”;Biochemistry(Mosc) (1998); vol. 63; pp. 69-73; [online] [retrieved on Aug. 28, 2003]. Retrieved from Internet: <URL: http://www.protein.bio.msu.su/biokhimiya/contents/v63/full/63010083.htm>.
Walker et al; “Distantly Related Sequences in the α- and β-subunits of ATP Synthase, Myosin, Kinases And Other ATP-Requiring Enzymes And A Common Nucleotide Binding Fold”;EMBO J., (1982); vol. 8; pp. 945-951; IRL Press Limited, Oxford, England.
Wall et al; “Factors Influencing Endothelial Cell Proliferation In Vitro”;J. Cell. Physiol., (1978); vol. 96; pp. 203-213.
Wessel et al; “Method for the Quantitative Recovery of Protein in Dilute Solution in the Presence of Detergents and Lipids”;Analytical Biochemistry, (1984); vol. 138; pp. 141-143.
Xia et al; “Tumor Necrosis Factor -α Induces Adhesion Molecule Expression Through The Sphingosine Kinase Pathway”;Proc. Natl. Acad. Sci. USA(Nov. 1998); vol. 95; pp. 14196-14201; The National Academy of Sciences.
H. Yu et al; “Structural Basis for the Binding of Proline-Rich Peptides to SH3 Domains”;CELL(Mar. 1994); vol. 76; pp. 933-945.
Hinkovska-Galcheva et al. “The Formation of Ceramide-1-Phosphate During Neutrophil Phagocytosis and its Role in Liposome Fusion”, The Journal of Biological Chemistry, vol. 273, No. 50 pgs. 33203-33209.
Kohama et al. “Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase”, The Journal of Biological Chemistry, vol. 273, No. 37 pp. 23722-23728.
Kolesnick et al. “Characterization of a Ceramide Kinase Activity from Human Leukemia (HL-60) Cells”, The Journal of Biological Chemistry, vol. 273, No. 31 pp. 18803-18808.
Nava et al, “Functional Characterization of Humn Sphingosine Kinase-1” FEBS Letters, vol. 473, No. 1, May 4, 2000, pp. 81-84.
Sue Y et al. “Sphingosine 1-Phosphate, a Novel Signaling Molecule,

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