Sphingomyelin enhancement of tumor therapy

Details Sphingomyelin enhancement of tumor therapy Sphingomyelin enhancement of tumor therapy

2007-10-30

2007-10-30

Pryor, Alton (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

C514S025000, C514S033000, C514S034000, C514S076000, C424S001490, C424S001110

Reexamination Certificate

active

10366704

ABSTRACT:
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing the levels of sphingomyelin in all cellular compartments, thereby providing sufficient substrate for activated sphingomyelinase. A method of treating rheumatoid arthritis also is provided.

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