Sphingolipid-derived pharmaceutical compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S183000

Reexamination Certificate

active

07629385

ABSTRACT:
The present invention relates to specific sphingolipids/sphingolipid derivatives as pharmaceutical compositions as well as their use in the preparation of medicaments for the treatment, prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.

REFERENCES:
patent: 19841794 (2000-03-01), None
patent: 1 291 430 (2003-03-01), None
patent: 08 113535 (1996-05-01), None
patent: WO 94/10991 (1993-10-01), None
patent: WO 98/02153 (1998-01-01), None
patent: WO 99/41266 (1999-08-01), None
patent: WO 00/59517 (2000-10-01), None
patent: WO 01/22957 (2001-04-01), None
patent: WO 2004/006483 (2004-05-01), None
Rosenwald et. al., The Journal of Biological Chemistry (1993) 268:4577-4579.
McReynolds et. al., Bioorganic and Medicinal Chemistry (2002) 10:625-637.
“Inhibitor against nerve cell degeneration or death—comprises N-acyl-sphingosine or sphingo-myelinase, used for treating degenerative diseases or injuries e.g. trauma and Alzheimer's disease,” Database WPI, Derwent Publications Ltd., AN 1996/272724, 1996.
Anderson et al., “Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae,”Molecular Biology of the Cell, 7: 1825-1834, 1996.
Damm et al., “Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae,”The Journal of Cellular Biology, 168: 477-488, 2005.
Gidwani et al., “Disruption of lipid order by short-chain ceramides correlates with inhibition of phospholipase D and downstream signaling by FcεRI,”Journal of Cell Science, 116: 3177-3187, 2003.
Hussey et al., “Synthesis of chimeric 7alpha-substituted estradiol derivatives linked to cholesterol and cholesterylamine,”Org. Lett., 4: 415-418, 2002.
Ito, “N-acylsphingosine and sphingomyelinase as inhibitors of neuron degeneration and death,” Chemicals Abstracts Service, Database accession No. 1996:464360, 1996.
Koskinen and Koskinen, “Sphingosine, an enigmatic lipid: a review of recent litature synthesis,”Synthesis, 1075-1091, 1998.
Koskinen and Koskinen, “Total synthesis of sphingosine and its analogs,”Methods of Enzymologys, 311:458-479, 1998.
Nguyen et al., “Practical synthetic route to functionalized rhodamine dyes,”Org. Lett., 5: 3245-3248, 2003.
Pelkmans et al., “Local Actin Polymerication and Dynamin Recruitment in SV40-Inuduced Internalization of Caveolae,”Science, 296: 535-539, 2002.
Pelkmans et al., “Caveolar endocytosis of simina virus 40 reveals a new two-step vesicular-transport pathway to the ER,”Nature Cell Biol., 3: 473-483, 2001.
Rosenwald and Pagano, “Inhibition of Glycoprotein Traffic through the Secretory Pathway by Ceramide,”The Journal of Biological Chemistry, 268: 4577-4579, 1993.
Sieczkarski and Whittaker, “Differential Requirements of Rab5 and Rab7 for Endocytosis of Influenza and Oether Enveloped Viruses,”Traffic, 4: 333-343.
Simons and Vaz, “Model Systems, lipid rafts, and cell membrances,”Annu. Rev. Biophys. Biomol. Struct., 33: 269-295, 2004.
Stang et al., “Major histocompatibility complex class I molecules mediate association of SV40 with caveolae,”Mol. Biol. Cell, 8: 47-57, 1997.
Wang et al., “Fluorescence-based evaluation of the partitioning of lipids and lipidated peptides into liquid-ordered lipid microdomains: a model for molecular partitioning into ‘lipid rafts’,”Biophys. J., 79: 919-933, 2000.
Wang et al., “Relationship between sterol/steroid structure and participation in ordered lipid domains (lipid rafts): implications for lipid raft structure and function,”Biochemistry, 43: 1010-1018, 2004.
European Search Report, mailed Oct. 17, 2007.
Rosenwald and Pagano, “Inhibition of glycoprotein traffic through the scretory pathway by ceramide,”J. Bio. Chem., 268:4577-4579, 1993.
European Search Report issued in European Application No. 08021735.9, mailed Aug. 6, 2009.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Sphingolipid-derived pharmaceutical compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sphingolipid-derived pharmaceutical compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sphingolipid-derived pharmaceutical compositions will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4134545

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.