Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Patent
1997-01-13
2000-08-15
Smith, Ruth S.
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
600407, 600476, 2504612, 356317, A61B 500
Patent
active
06104945&
ABSTRACT:
Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes a source of electromagnetic radiation, an optical assembly and a detector. The optical assembly sequentially illuminates a plurality of volume elements in the sample with an intensity distribution in the sample that drops off substantially monotonically from a first region in a first optical path and collects electromagnetic radiation emanating from each of the volume elements. The optical assembly collects the electromagnetic radiation emanating from each of the volume elements with a collected distribution that drops off substantially monotonically from a second region in a second optical path. The first and second regions at least partially overlap in each of the volume elements. The detector detects the collected electromagnetic radiation emanating from each of the sequentially illuminated volume elements to produce responses representative of the characteristic in each of the volume elements.
REFERENCES:
patent: Re34214 (1993-04-01), Charlsson et al.
patent: 3013467 (1961-12-01), Minsky
patent: 4017192 (1977-04-01), Rosenthal
patent: 4198571 (1980-04-01), Sheppard
patent: 4254421 (1981-03-01), Kreutel, Jr.
patent: 4357075 (1982-11-01), Hunter
patent: 4397557 (1983-08-01), Herwig et al.
patent: 4733063 (1988-03-01), Kimura et al.
patent: 4753530 (1988-06-01), Knight et al.
patent: 4844617 (1989-07-01), Kelderman et al.
patent: 4845352 (1989-07-01), Benschop
patent: 4852955 (1989-08-01), Doyle et al.
patent: 4930516 (1990-06-01), Alfano et al.
patent: 4965441 (1990-10-01), Picard
patent: 4972258 (1990-11-01), Wolf et al.
patent: 4997242 (1991-03-01), Amos
patent: 5011243 (1991-04-01), Doyle et al.
patent: 5028802 (1991-07-01), Webb et al.
patent: 5032720 (1991-07-01), White
patent: 5034613 (1991-07-01), Denk et al.
patent: 5042494 (1991-08-01), Alfano
patent: 5054926 (1991-10-01), Dabbs et al.
patent: 5065008 (1991-11-01), Hakamata et al.
patent: 5071246 (1991-12-01), Blaha et al.
patent: 5074306 (1991-12-01), Green et al.
patent: 5083220 (1992-01-01), Hill
patent: 5091652 (1992-02-01), Mathies et al.
patent: 5120953 (1992-06-01), Harris
patent: 5122653 (1992-06-01), Ohki
patent: 5132526 (1992-07-01), Iwasaki
patent: 5139025 (1992-08-01), Lewis et al.
patent: 5161053 (1992-11-01), Dabbs
patent: 5162641 (1992-11-01), Fountain
patent: 5162941 (1992-11-01), Favro et al.
patent: 5168157 (1992-12-01), Kimura
patent: 5192980 (1993-03-01), Dixon et al.
patent: 5201318 (1993-04-01), Rava et al.
patent: 5225671 (1993-07-01), Fukuyama
patent: 5235457 (1993-08-01), Lichtman et al.
patent: 5239178 (1993-08-01), Derndinger et al.
patent: 5248876 (1993-09-01), Kerstens et al.
patent: 5260569 (1993-11-01), Kimura
patent: 5260578 (1993-11-01), Bliton et al.
patent: 5262646 (1993-11-01), Booket et al.
patent: 5274240 (1993-12-01), Mathies et al.
patent: 5284149 (1994-02-01), Dhadwal et al.
patent: 5286964 (1994-02-01), Fountain
patent: 5294799 (1994-03-01), Aslund et al.
patent: 5296700 (1994-03-01), Kumagai
patent: 5303026 (1994-04-01), Stobl et al.
patent: 5306902 (1994-04-01), Goodman
patent: 5313567 (1994-05-01), Civanlar et al.
patent: 5319200 (1994-06-01), Rosenthal et al.
patent: 5324979 (1994-06-01), Rosenthal
patent: 5329352 (1994-07-01), Jacobsen
patent: 5343038 (1994-08-01), Nishiwaki et al.
patent: 5345306 (1994-09-01), Ichimura et al.
patent: 5418797 (1995-05-01), Bashkansky et al.
patent: 5421337 (1995-06-01), Richards-Kortum et al.
patent: 5451931 (1995-09-01), Muller et al.
patent: 5477382 (1995-12-01), Pernick
patent: 5480775 (1996-01-01), Ito et al.
patent: 5493444 (1996-02-01), Khourv et al.
patent: 5587832 (1996-12-01), Krause
patent: 5713364 (1998-02-01), DeBaryshe et al.
N. Ramanujam et al, "In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence", Proc. Natl. Acad. Sci. USA, vol. 91, Pp. 10193-10197, Oct. 1994.
N. Ramanujam et al, Fluorescence Spectroscopy: A Diagnostic Tool for Cervical Intraepithelial Neoplasa (CIN), Gynecologic Oncology 52, pp. 31-38 (1994).
Kevin T. Schomacker, et al. "Ultraviolet Laser-Induced Fluorescence of Colonic Tissue: Basic Biology and Diagnostic Potential", Lasers in Surgery and Medicine, 12: 63-78, (1992).
Jeffrey W. Hall, et al, "Near-Infrared Spectrophotometry: A New Dimension in Clinical Chemistry", Clin. Chem. 38/9, 1623-1631 (1992).
R. Richards-Kortum et al, "Description and Performance of a Fiber-Optic Confocal Fluorescence Spectrometer", Applied Spectroscopy, vol. 48, No. 3, pp. 350-355, (1994).
S. Schwartz, "Real-time laser-scanning confocal ratio imaging", American Laboratory, pp. 53-62, Apr. 1993.
P. Davidovits et al, "Scanning Laser Microscope for Biological Investigations", Applied Optics, vol. 10, No. 7, pp. 1615-1619, Jul. 1971.
C. Koester, "Comparison of Optical Sectioning Methods: The Scanning Slit Confocal Microscope", Confocal Microscopy Handbook, pp. 189-194.
J.M. Schmitt et al, "Confocal Microscopy in Turbid Media", Biomed. Eng. And Inst. Program, NCRR, National Institute of Health, Bethesda, MD 20892, pp. 1-46.
S.G. Anderson, "Confocal Laser Microscopes See A Wider Field of Application", Laser Focus World, pp. 83-86, Feb. 1994.
T. Wilson, "The Role of th Pinhole in Confocal Imaging Systems", Confocal Microscopy Handbook, pp. 99-113.
C.J.R. Sheppard et al, "Depth of Field in the Scanning Microscope", Optics Letters, vol. 3, No. 3 Sep. 1978, pp. 115-117.
C.J. Koester, "Scanning Mirror Microscope with Optical Sectioning Characteristics: Applications in Ophthalmology", Applied Optics, vol. 19, No. 11, Jun. 1980, pp. 1749-1757.
J.M. Schmitt et al, "Interferometric Versus Confocal Techniques for Imaging Microstructures in Turbid Biologocal Media", Proc. SPIE, 2135 (1994), pp. 1-2.
Hed A. Ze'ev
Modell Mark
MediSpectra, Inc.
Smith Ruth S.
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