Specific inhibitors of NFAT activation by calcineurin and...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S324000, C530S326000, C530S328000

Reexamination Certificate

active

07084241

ABSTRACT:
Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein—protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided.

REFERENCES:
patent: 5612455 (1997-03-01), Hoey
patent: 5656452 (1997-08-01), Rao et al.
patent: 5708158 (1998-01-01), Hoey
patent: 5837840 (1998-11-01), Crabtree et al.
patent: 6096515 (2000-08-01), Crabtree et al.
patent: 6150099 (2000-11-01), Crabtree et al.
patent: 6171781 (2001-01-01), Crabtree et al.
patent: 6197925 (2001-03-01), Crabtree et al.
patent: 6352830 (2002-03-01), Crabtree et al.
patent: WO 93/22338 (1993-11-01), None
patent: WO 94/03205 (1994-02-01), None
patent: WO 94/18234 (1994-08-01), None
patent: WO 94/20127 (1994-09-01), None
patent: WO 96/26959 (1996-09-01), None
Yan et al., Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science 290: 523-527, 2000.
Mickle JE et al. Genotype-phenotype relationships in cystic fibrosis. Med Clin North Am. May 2000;84(3):597-607.
Voet et al. Biochemistry. 1990. John Wiley & Sons, Inc. pp. 126-128 and 228-234.
Clipstone et al., “Identification of Calcineurin as a Key Signalling Enzyme in T-lymphocyte Activation”Nature 357:695-697, 1992.
Loh et al., “Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity”Biological Chemistry 271(18):10884-10891, 1996.
Luo et al., “Interaction of Calcineurin With a Domain of the Transcription Factor NFAT1 that Controls Nuclear Import”Biochemistry 93:8907-8912, 1996.
Masuda et al., “Control of NFATx1 Nuclear Translocation by a Calcineurin-Regulated Inhibitory Domain”Molecular and Cellular Biology 17(4):2066-2075, 1997.
Park et al., “Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T Cells”Biological Chemistry 270(35):20653-20659, 1995.
Ruff et al., “Direct Demonstration of NFATp Dephosphorylation and Dephosphorylation and Nuclear Localization in Activated HT-2 Cells Using a Specific NFAT9 . . . ”Bio. Chem. V. 270:22602-22607, 1995.
Shaw et al., “Immunosuppressive Drugs prevent a Rapid Dephosphorylation of Transcription Factor NFAT1 in Stimulated Immune Cells”Cell Biology 92:11205-11209, 1995.
Shibasaki et al., “Role of Kinases and the Phosphatase Calcineurin in the Nuclear Shuttling of Transcription Factor NF-AT4”Nature 382:370-373, 1996.
Timmerman et al., Rapid shuttling of NF-AT in Discrimination of Ca2 signals and ImmunosuppressionNature 383:837-840, 1996.
Wesselborg, Sebastian et al., “Identification of a Physical Interaction between Caloineurin and Nuclear Factor of Activated T Cells (NFATp)”, Biological Chemistry 271(3):1274-1277, 1996.
Rao, Amjane et al. “Transcription Factors of the NFAT Family: Regulation and Function”, Annual Reviews, Inc. 15:707-747, 1997.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Specific inhibitors of NFAT activation by calcineurin and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Specific inhibitors of NFAT activation by calcineurin and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Specific inhibitors of NFAT activation by calcineurin and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3713148

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.