Spatially scanned optical reader system and method for using...

Details Spatially scanned optical reader system and method for using... Spatially scanned optical reader system and method for using...

2004-12-29

2009-10-20

Nguyen, Bao-Thuy L (Department: 1641)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C422S082050, C422S082090, C422S082110, C385S012000, C385S037000, C356S244000, C356S073100, C356S300000, C356S328000, C359S263000, C359S196100, C436S164000

Reexamination Certificate

active

07604984

ABSTRACT:
An optical reader system is described herein that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. In one embodiment, the optical reader system includes a light source, a detector and a processor (e.g., computer, DSP). The light source outputs an optical beam which is scanned across a moving biosensor and while this is happening the detector collects the optical beam which is reflected from the biosensor. The computer processes the collected optical beam and records the resulting raw spectral or angle data which is a function of a position (and possibly time) on the biosensor. The processor can then analyze the raw data to create a spatial map of resonant wavelength (peak position) or resonant angle which indicates whether or not a biomolecular binding event occurred on the biosensor. Several other uses of the raw data are also described herein.

REFERENCES:
patent: 4710031 (1987-12-01), Kelly et al.
patent: 4815843 (1989-03-01), Tiefenthaler et al.
patent: 4992385 (1991-02-01), Godfrey
patent: 5047651 (1991-09-01), Wessner et al.
patent: 5310686 (1994-05-01), Sawyers et al.
patent: 5340715 (1994-08-01), Slovacek et al.
patent: 5592289 (1997-01-01), Norris
patent: 5631170 (1997-05-01), Attridge
patent: 5738825 (1998-04-01), Rudigier et al.
patent: 5822073 (1998-10-01), Yee et al.
patent: 6258326 (2001-07-01), Modlin
patent: 6312961 (2001-11-01), Voirin et al.
patent: 6346376 (2002-02-01), Sigrist et al.
patent: 6455004 (2002-09-01), Tiefenthaler
patent: 6709869 (2004-03-01), Mian et al.
patent: 6738141 (2004-05-01), Thirstrup
patent: 6787110 (2004-09-01), Tiefenthaler
patent: 6829073 (2004-12-01), Krol et al.
patent: 6884628 (2005-04-01), Hubbell et al.
patent: 7057720 (2006-06-01), Caracci et al.
patent: 2002/0009391 (2002-01-01), Marquiss et al.
patent: 2002/0090320 (2002-07-01), Burow et al.
patent: 2002/0127565 (2002-09-01), Cunningham et al.
patent: 2002/0132261 (2002-09-01), Dorsel et al.
patent: 2002/0168295 (2002-11-01), Cunningham et al.
patent: 2003/0007896 (2003-01-01), Tiefenthaler
patent: 2003/0017580 (2003-01-01), Cunningham et al.
patent: 2003/0017581 (2003-01-01), Li et al.
patent: 2003/0026891 (2003-02-01), Qiu et al.
patent: 2003/0027327 (2003-02-01), Cunningham et al.
patent: 2003/0027328 (2003-02-01), Cunningham et al.
patent: 2003/0032039 (2003-02-01), Cunningham et al.
patent: 2003/0059855 (2003-03-01), Cunningham et al.
patent: 2003/0067612 (2003-04-01), Ivarsson
patent: 2003/0068657 (2003-04-01), Lin et al.
patent: 2003/0077660 (2003-04-01), Pien et al.
patent: 2003/0092075 (2003-05-01), Pepper
patent: 2003/0113766 (2003-06-01), Pepper et al.
patent: 2003/0133640 (2003-07-01), Tiefenthaler
patent: 2003/0169417 (2003-09-01), Atkinson et al.
patent: 2003/0219809 (2003-11-01), Chen et al.
patent: 2004/0091397 (2004-05-01), Picard
patent: 2004/0132172 (2004-07-01), Cunningham et al.
patent: 2004/0132214 (2004-07-01), Lin et al.
patent: 2004/0132606 (2004-07-01), Wolff et al.
patent: 2004/0151626 (2004-08-01), Cunningham et al.
patent: 2004/0166496 (2004-08-01), Leproust et al.
patent: 2004/0223881 (2004-11-01), Cunningham et al.
patent: 2004/0247486 (2004-12-01), Tiefenthaler
patent: 2005/0014135 (2005-01-01), Hill et al.
patent: 2005/0070027 (2005-03-01), Gollier et al.
patent: 2005/0088648 (2005-04-01), Grace et al.
patent: 2005/0099622 (2005-05-01), Caracci et al.
patent: 2005/0153290 (2005-07-01), Van Beuningen
patent: 2005/0236554 (2005-10-01), Fontaine et al.
patent: 2006/0106557 (2006-05-01), Fontaine et al.
patent: 2006/0141527 (2006-06-01), Caracci et al.
patent: 0 202 021 (1986-11-01), None
J. Dübendorfer et al., “Sensing and Reference Pads for Integrated Optical Immunosensors”, Journal of Biomedical Optics, vol. 2, No. 4, Oct. 1997, pp. 391-400.
K. Tiefenthaler et al., “Integrated Optical Switches and Gas Sensors”, Optics Letters, vol. 10, No. 4, Apr. 1984, pp. 137-139.
M. Wiki et al., “Wavelength-Interrogated Optical Sensor for Biochemical Applications”, Optics Letters, vol. 25, No. 7, Apr. 1, 2000, pp. 463-465.
K. Cottier et al., “Label-Free Highly Sensitive Detection of (Small) Molecules by Wavelength Interrogation of Integrated Optical Chips”, Sensors and Actuators B, vol. 91, 2003, pp. 241-251.
K. Tiefenthaler et al., “Sensitivity of Grating Couplers as Integrated-Optical Chemical Sensors”, J. Opt. Soc. Am. B., vol. 6, No. 2, Feb. 1989, pp. 209-220.
W. Lukosz, “Integrated Optical Chemical and Direct Biochemical Sensors”, Sensors and Actuators B, vol. 29, 1995, pp. 37-50.
M. Wiki et al., “Novel Integrated Optical Sensor Based on a Grating Coupler Triplet”, Biosensors & Bioelectronics, vol. 13, 1998, pp. 1181-1185.
M.J. O'Brien II et al., “SPR Biosensors: Simultaneously Removing Thermal and Bulk-Composition Effects”, Biosensors & Bioelectronics, vol. 14, 1999, pp. 145-154.
L.G. Mendoza et al., High-Throughput Microarray-Based Enzyme-Linked Immunosorbent Assay (ELISA), BioTechniques, vol. 27, No. 4, 1999, pp. 778-788.
J.X. Huang et al., “High-Throughput Genomic and Proteomic Analysis Using Microarray Technology”, Clinical Chemistry, vol. 47, No. 10, pp. 1912-1916.
T. Wilkop et al., “Analysis of μ-Contact Printed Protein Patterns by SPR Imaging with a LED Light Source”, Langmuir, 2004, vol. 20, pp. 11141-11148.
T.E. Plowman et al., “Multiple-Analyte Fluoroimmunoassay Using an Integrated Optical Waveguide Sensor”, Analytical Chemistry 1999, vol. 71, No. 19, Oct. 1, 1999, pp. 4344-4352.
D. Nedelkov et al., “Surface plasmon resonance mass spectrometry: recent progress and outlooks”. TRENDS in Biotechnology, vol. 21, No. 7, Jul. 2003, pp. 301-305.
M. Bilban et al., “Normalizing DNA Microarray Data”, Curr. Issues Mol. Bol., 2002, vol. 4, pp. 57-64.
Q. Xu et al., “Protein and Chemical Microarrays—Powerful Tools for Proteomics”, Journal of Biomedicine and Biotechnology, 2003, vol. 5, pp. 257-266.
S. Venkatasubbarao, “Microarrays—status and prospects”, TRENDS in Biotechnology, vol. 22, No. 12, Dec. 2004, pp. 630-637.
M. Schaferling et al., “Protein Microarray Surface Chemistry and Coupling Schemes”, Protein Microarray Technology, Jan. 15, 2004, ISBN: 3-527-30597-1, URL:http://www3.interscience.wiley.com/cgi-bin/booktext/107061764/BOOKPDFSTART>, pp. 11-38.

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