Organic compounds -- part of the class 532-570 series – Organic compounds – Radioactive metal containing
Reexamination Certificate
2008-01-22
2008-01-22
Jones, Dameron L. (Department: 1618)
Organic compounds -- part of the class 532-570 series
Organic compounds
Radioactive metal containing
C534S010000, C534S015000, C534S016000, C424S001110, C424S001650
Reexamination Certificate
active
07321027
ABSTRACT:
The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tumors, e.g., carcinomas, melanomas and other tumors. In another embodiment, the invention relates to methods of imaging tumors using radiolabeled metal complexes. Preferred radiolabeled complexes for imaging tumors include technetium and rhenium complexes. The high tumor uptake and significant tumor
ontumor ratios of the technetium complexes of the invention indicate that such small technetium-99m-based molecular probes can be developed as in-vivo diagnostic agents for melanoma and its metastases. In yet another embodiment, the invention relates to methods of treatment of tumors using a radiolabeled metal complex as a radiopharmaceutical agent to treat the tumor.
REFERENCES:
patent: 4638051 (1987-01-01), Burns et al.
patent: 5919934 (1999-07-01), John et al.
patent: 0 200 211 (1986-11-01), None
P. Auzeloux et al. “A Potential Melanoma Tracer: Synthesis, Radiolabeling, and Biodistribution in Mice of a New Nitridotechnetium Bis (aminothiol) Derivative Pharmacomodulated by a N (Diethylaminoethyl) benzamide,” J. Med. Chem. 2000, 43, 190-198.
John et al. “99mTc-Labeled σ-Receptor-Binding Complex: Synthesis, Characterization, and Specific Binding to Human Ductual Breast Carcinoma (T47D) Cells,” Bioconjugate Chem. 8:304-309 (1997).
Bolzati Cristina
Davison Alan
Friebe Matthias
Jones Alun G.
Mahmood Ashfaq
Edwards Angell Palmer & & Dodge LLP
Jones Dameron L.
Massachusetts Institute of Technology
Neuner George W.
President and Fellows of Harvard College
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