Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-22
2011-03-22
Solola, Taofiq A (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S401000
Reexamination Certificate
active
07910621
ABSTRACT:
The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).
REFERENCES:
Cain, (London) J. of the Chem. Soc. (1964), Part V, pp. 5472-5474.
Cain, (London) J. of the Chem. Soc. (1963), Part I, pp. 356-359.
Database CAPLUS Acc. No. 1963:59491, CA 58:59491, Cain BF Potential antitumor agents II. polyporic acid series', see abstract.
Database CAPLUS Acc. No. 1965:36588, Doc. No. 62:36588, Cain BF Potential antitumor agents. III. polyporic acid, see abstract.
Chen Jianyong
Hu Zengjian
Nikolovska-Coleska Zaneta
Sun Haiying
Wang Shaomeng
Casimir Jones SC
Solola Taofiq A
The Regents of the University of Michigan
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