Slow release bolus

Details Slow release bolus Slow release bolus

1976-04-26

1978-01-03

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424227, 424359, A61K 31635, A61K 3165, A61K 4700

Patent

active

040667545

ABSTRACT:
A composition for slowly releasing a veterinary medicament in a ruminant animal is described. The composition comprises a water-insoluble and water resistant binder a therapeutically active substance and a critical water-insoluble controlled release agent. The process of the invention includes the steps of adding a solution of a water-insoluble binder dissolved in an organic solvent to a mixture of a therapeutically active substance and a water-insoluble dense filler, stirring the mixture until free flowing granules are formed, drying the granules, blending the dried granules with a lubricant and a water insoluble controlled release agent and compressing the mixture into convenient veterinary dosage forms. When the veterinary composition is orally administered to a ruminant animal it remains in the animal's body for a desired period of time and the therapeutically active substance contained therein is released in a predictable and controllable pattern.

REFERENCES:
patent: 2895880 (1959-07-01), Rosenthal
patent: 3181998 (1965-05-01), Kanig

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