SKN-1 and GSK-3 genes and proteins

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C800S008000, C424S009200

Reexamination Certificate

active

07572949

ABSTRACT:
The present invention relates, in part, to theC. elegansSKN-1 gene and protein (a transcription factor), and target genes thereof. The invention includes various therapeutic methods and screening methods for identifying antioxidants.

REFERENCES:
Bhat et al., “Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418,”J. Biol. Chem., 278:45937-45945 (2003).
Blackwell et al., “Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements,”Science, 266:621-628 (1994).
Bowerman et al., “skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the earlyC. elegansembryo,”Cell, 68:1061-1075 (1992).
Bowerman et al., “The maternal gene skn-1 encodes a protein that is distributed unequally in earlyC. elegansembryos,”Cell, 74:443-452 (1993).
C. elegansSequencing Consortium, “Genome sequence of the nematodeC. elegans: a platform for investigating biology,”Science, 282:2012-2018 (1998).
Cohen et al., “The renaissance of GSK3,”Mol. Cell Biol., 2:769-776 (2001).
Delaunay et al., “A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation,”Cell, 111:471-481 (2002).
Gaudet et al., “Regulation of organogenesis by theCaenorhabditis elegansFoxA protein PHA-4,”Science, 295:821-825 (2002).
Hayes et al., “Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention,”Cancer Letters, 174:103-113 (2001).
Itoh et al., “Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain,”Genes Dev., 13:76-86 (1999).
MacAulay et al., “Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase,”Eur. J. Biochem., 270:3829-3838 (2003).
Maduro et al., “Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3beta homolog is mediated by MED-1 and -2 inC. elegans,” Mol. Cell., 7:475-485 (2001).
Nguyen et al., “Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome,”J. Biol. Chem., 278:4536-4541 (2003).
Stein et al., “WormBase: network access to the genome and biology ofCaenorhabditis elegans,” Nucleic Acids Research, 29:82-86 (2001).
Sekhar et al., “Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2,”Oncogene, 21:6829-6834 (2002).
Stewart et al., “Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium,”J. Biol. Chem., 278:2396-2402 (2003).
Thatcher et al., “TheCaenohabditis eleganspeb-1 gene encodes a novel DNA-binding protein involved in morphogenesis of the pharynx, vulva, and hindgut,”Dev. Biol., 229:480-493 (2001).
Toone et al., “AP-1 transcription factors in yeast,”Curr. Opin. Genet. Div., 9(1):55-61 (1999).
Toone et al., “Redox control of AP-1-like factors in yeast and beyond,”Oncogene, 20:2336-2346 (2001).
WormBase reference #F37B12.2.
WormBase reference #F39B2.3.
WormBase reference #M176.2.
WormBase reference #T19E7.
Walker et al., “A conserved transcription motif suggesting functional parallels betweenCaenorhabditis elegansSKN-1 and Cap'n'Collar-related basic leucine zipper proteins,”J. Biol. Chem., 275:22166-22171 (2000).
Yost et al., “GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis,”Cell, 93:1031-1041 (1998).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

SKN-1 and GSK-3 genes and proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with SKN-1 and GSK-3 genes and proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and SKN-1 and GSK-3 genes and proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4083830

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.