Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-08-15
2000-12-05
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 724, 435 78, 435 79, 435 792, 435 793, 435 795, 530324, 530402, G01N 3353
Patent
active
061565202
ABSTRACT:
The present invention encompasses polypeptides that comprise a chemokine receptor binding sequence and are useful in determining the affinity of a compound for a chemokine receptor. Substitution of one of the amino acids of the C-terminal region of the polypeptide with a cysteine enables the polypeptide to be detectably labelled without loss of receptor binding activity and without the problems inherent in radioiodine labelling. Methods for use of the polypeptides in competitive binding assays are also disclosed.
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Appell Kenneth C.
Burbaum Jonathan J.
Inglese James
Samama Philippe
Stroke Ilana L.
Pharmacopeia Inc.
Stucker Jeffrey
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