Expression of antigenic Epstein-Barr virus polypeptides in bacte

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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530402, 530403, 530806, 530826, 424 89, 4353201, A61K 39245, C07K 1504, C07K 1300

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active

052567680

ABSTRACT:
Bacterially synthesized polypeptides that are recognized by antibodies produced in EBV-infected humans are disclosed. Plasmids containing DNA sequences encoding portions of the EBNA and EBEA-D antigens are also disclosed, as are methods for expressing these DNA sequences in bacteria. The DNA sequence encoding the EBNA-1-related fusion polypeptide is found in a Bam H1 K-restriction fragment, while that encoding the EBEA-D-related fusion polypeptide is found in a Bam H1 M-restriction fragment.

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