Sirtuin modulating compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S366000

Reexamination Certificate

active

07345178

ABSTRACT:
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

REFERENCES:
patent: 4018932 (1977-04-01), Spicer et al.
patent: 2004/0176396 (2004-09-01), Biftu et al.
patent: 2005/0245539 (2005-11-01), Mendla et al.
patent: 1 402 689 (1975-08-01), None
patent: 50-76084 (1975-06-01), None
patent: 52-89689 (1977-07-01), None
patent: 07 291976 (1995-11-01), None
patent: WO-01/27119 (2001-04-01), None
patent: WO-03/007959 (2003-01-01), None
patent: WP-03/11219 (2003-02-01), None
patent: WO-03/028725 (2003-04-01), None
patent: WO-03/028728 (2003-04-01), None
patent: WO-03/042188 (2003-05-01), None
patent: WO-2004/080481 (2004-09-01), None
patent: WO-2005/058884 (2005-06-01), None
patent: WO-2005/069998 (2005-08-01), None
Andreani, et al., “6-(Hydroxyphenyl) Imidazo [2,1-b]Thiazoles as Potential Antiinflammatory Agents: Effects on Human Neutrophil Functions,”Collection of Czechoslovak Chemical Communications, 65:267-279 (2000).
Andreani, et al., “Synthesis and antitubercular activity of imidazol[2,1-b]thiazoles,”European Journal of Medicinal Chemistry, 36:743-746 (2001).
Andreani, et al., “Synthesis and antitumor activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones,”Anti-Cancer Drug Design, 16:167-174 (2001).
Andreani, et al.,“Thienylimidazo[2,1-b]thiazoles as Inhibitors of Mitochondrial NADH Dehydrogenase,”Journal of Medicinal Chemistry, 38:1090-1097 (1995).
Barchechath, et al., “Inhibitors of Apoptosis in Lymphocytes: Synthesis and Biological Evaluation of Compounds Related to Pifithrin-α,”Journal of Medicinal Chemistry, 48:6409-6422 (2005).
Bienayme and Bouzid et al., “A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-Aminoimidazoles,”Angewandte Chemie International Edition, 37(16):2234-2237 (1998).
Forti, et al., “NADPH-generating system: influence on microsomal mono-oxygenase stability during incubation for the liver-microsomal assay with rat and mouse S9 fractions,”Mutation Research, 129:291-297 (1984).
Freymann, et al., Efficient identification of inhibitors targeting the closed active site conformation of the HPRT fromTrypansoma cruzi, Chemistry and Biology, 7:957-968 (2000).
Gemesi, et al., “Application of LC-MS analysis to the characterisation of the in vitro and in vivo metabolite profiles of RGH-1756 in the rat,”Journal of Pharmaceutical and Biomedical Analysis, 24:877-885 (2001).
Hozien, et al., “An Efficient Route for Synthesis of 5,6-Diphenylimidazo-[2,1-b]thiazoles as Antibacterial Agents,”Journal of Heterocyclic Chemistry, 37:943-949 (2000).
Ikeda, et al., “Functional analysis of four naturally occuring variants of human constitutive androslane receptor,”Molecular Genetics and Metabolism, 86:314-319 (2005).
Jinno, et al., “Identification of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor and Characterization of Their Expression in the Liver,”Molecular Pharmacology, 65(3):496-502 (2004).
Laszlovszky, et al., “Substituted phenoxyalkylpiperazines as dopamine D3receptor ligands,”Pharmazie, 56(4):287-289 (2001).
Lewis, et al., “Levamisole-Resistant Mutants of the NematodeCaenorhabditis elegansAppear to Lack Pharmacological Acetylcholine Receptors,”Neuroscience, 5;967-989 (1980).
Terjeki, et al., “An HPLC/UV method for the determination of RGH-1756 in dog and rat plasma,”Journal of Pharmaceutical and Biomedical Analysis, 24:913-920 (2001).
Yagodinets, et al., “Convenient method for the synthesis of phosphorus-containing heterocyclic systems of imidazo[2,1-b]thiazoles, imidazo[2,1-a]pyridines and quinoxalines,”Zhurnal Obshchei Khimii, 54(12):2789-2790 (1984).
Yueh, et al., “High Volume Bioassays to Assess CYP3A4-Mediated Drug Interactions: Induction and Inhibition in a Single Cell Line,”Drug Metabolism and Disposition, 33(1):38-48 (2005).
Porcu, et al., “The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension,” TRENDS in Pharmacological Sciences, 26(2):94-103 (2005).
Database Chemcats Chemical Abstracts Service, Columbus, OH, US; Jan. 18, 2005 (Jan. 18, 2005), XP002384121 ON's STK199474, STK199472, STK199473, STK180355, STK174405, STK196060, STK115373, STK164162, STK136073, STK164152, STK120473, STK052285 -& “Interchim Intermediates” Jan. 18, 2005 (Jan. 18, 2005), Interchim, Montlucon, France, XP002386059.

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