Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1984-12-18
1988-07-19
Hazel, Blondel
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
424 85, 435811, E12P 2100, A61K 4502
Patent
active
047585102
ABSTRACT:
Interferon is produced in-vitro from whole blood, obtainable from animals or humans including blood from corpses or retroplacental blood, in a simplified non-critical process preferably carried out in a sterile system of interconnected plastic bags. The blood is stabilized and innoculated with an interferon inducer before culturing in an incubator. This results in interferon containing blood useful directly for transfusions or further processable to obtain a variety of therapeutic interferon containing preparations including plasma, serum and albumin in accordance with disclosed phases of this invention. Interferon carrying plasma is thus separated and treated further to isolate interferon carrying serum or albumin, if desired. In-vivo innoculation to produce antibodies before taking blood provides improved disease fighting characteristics in the derived product. Steps are provided for purification of the products such as removal of residual inducers or the treatment for presence of suspected hepatitis virus, etc.
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Morgensen K, et al., Pharm. Therm. A., vol. 1, pp. 369-381, 1977.
Interferon and Their Action, W. E. Stewart II, Editor, Hanell, "Cellular Regulatory Mechanism Controlling Synthesis of Interferony", pp. 37-38, 1977.
Skurkovich et al., Biomedicine, vol. 29, pp. 227-228, 1978.
Skurkovich Boris
Skurkovich Simon V.
Hazel Blondel
S.V.S. Laboratories, Inc.
Wells Gilbert L.
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