Serine protease operative between 75.degree.C. and 103.degree.C.

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

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435219, 435 681, 435 691, 4352523, 43525231, 43525233, 4353204, 435262, 510300, 536 232, C12N 952, C12N 1557, C12N 1570, C11D 3386

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058307400

ABSTRACT:
A subtilisin which exhibits proteolytic activity at temperatures ranging from 75.degree. C. to 130.degree. C. The subtilisin has been given the name aerolysin because it was initially isolated from the hyperthermophilic archaeum, Pyrobaculum aerophilum. The amino acid sequence of aerolysin is disclosed as well as the nucleotide sequence which encodes the enzyme. Aerolysin and related modified enzymes are useful as high temperature detergent additives and, among other things, may be used in combination with a wide variety of other detergent agents.

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